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Alpha-sarcin catalytic activity is not required for cytotoxicity.

Alford(Spencer C),Pearson(Joel D),Carette(... BMC Biochem 2009-06-02

...RPS6.,We conclude that although protein synthesis inhibition likely contributes to cell death, it is not required. Thus,...

The ZW sex chromosomes of Gekko hokouensis (Gekkonidae, Squamata) represent h...

Kawai(Aya),Ishijima(Junko),Nishida(Chizuko... Chromosoma 2009-03-17

...RPS6-DMRT1-CHD1-GHR-ATP5A1, indicating that the origin of ZW chromosomes in G. hokouensis is the same as that in the cla...

Pivotal role of mTOR signaling in hepatocellular carcinoma.

Villanueva(Augusto),Chiang(Derek Y),Newell... Gastroenterology 2009-01-06

...RPS6) was present in half of the cases, associated with insulin-like growth factor pathway activation, epidermal growth ...

Mutual regulation of hypoxia-inducible factor and mammalian target of rapamyc...

Knaup(Karl X),Jozefowski(Katrin),Schmidt(R... Mol Cancer Res 2009-02-26

...rpS6 negatively correlate in experimental tumors. In cell culture, prolonged hypoxia abolishes rpS6 phosphorylation, whi...

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase ...

Welle(Stephen),Burgess(Kerri),Mehta(Sangeeta) Am J Physiol Endocrinol Met... 2009-04-20

...rpS6) 1.9-fold (P < 0.05). It did not affect phosphorylation of eukaryotic initiation factor 4E-binding protein-1 or Akt...

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathwa...

Salmond(Robert J),Emery(Juliet),Okkenhaug(... J Immunol 2009-12-22

...rpS6 phosphorylation, further linking rpS6 to control of cellular metabolism. rpS6 is essential in T cells because its d...

EGFR signals to mTOR through PKC and independently of Akt in glioma.

Fan(Qi-Wen),Cheng(Christine),Knight(Zachar... Sci Signal 2009-03-18

...rpS6 (p-rpS6) in cells wild type for the gene encoding PTEN (phosphatase and tensin homolog on chromosome 10), a negativ...

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipul...

Reddy(Pradeep),Adhikari(Deepak),Zheng(Wenj... Hum Mol Genet 2009-10-14

...rpS6) signaling in oocytes appears to be responsible for the loss of primordial follicles, and mice lacking the Rps6 gen...

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway.

Presneau(N),Shalaby(A),Idowu(B),Gikas(P),C... Br J Cancer 2009-05-14

...RPS6 (22%), p-4E-BP1 (96%) and eIF-4E (98%). Phosphatase and tensin homologue deleted on chromosome 10 expression was lo...

Melatonin down-regulates HIF-1 alpha expression through inhibition of protein...

Park(Jong-Wook),Hwang(Mi-Sun),Suh(Seong-Il... J Pineal Res 2009-09-17

...RPS6, a pathway known to regulate HIF-1 alpha expression at the translational level. Metabolic labeling assays indicated...

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