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Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and…

Wu(ZH),Yi(C),Chen(EX),Xu(JQ),Li(C),Yao(L),Li… Proc Natl Acad Sci U S A 2025-05-06

...TEAD4). Furthermore, MYBL2 facilitates the differentiation of hTSCs into extravillous trophoblast (EVT) by positively re...

Super-Enhancers in Placental Development and Diseases.

Rosario(GX),Brown(S),Karmakar(S),Rumi(MAK),N… J Dev Biol 2025-04-09

...TEAD4, along with their binding sites and cis-regulatory elements, have been studied for their roles in trophoblast cell...

Integrative analysis of bulk RNA and single-cell sequencing data reveals a liqu…

Wang(H),Liu(Z),Zhang(L),Cheng(X),Du(Y),Guo(Y… Gene 2025-04-15

...TEAD4, KMT5C, TRNP1, and SGO1, was identified by univariate Cox and least absolute shrinkage and selection operator algo...

Hypomethylation Causes MIR21 Overexpression in Tumors.

Lu(J),Tan(T),Zhu(L),Dong(H),Xian(R) Mol Ther Oncolytics 2020-09-25

...TEAD4, which were co-expressed with miR-21 in tumors. These observations identified that gene hypomethylation regulated ...

Argonaute 2 is a key regulator of maternal mRNA degradation in mouse early embr…

Zhang(JM),Hou(WB),Du(JW),Zong(M),Zheng(KL),W… Cell Death Discov 2020-11-27

...Tead4, triggering ZGA-dependent MRD. Thus, Ago2-dependent degradation is required for timely elimination of subgroups of...

Association of subcellular localization of TEAD transcription factors with outc…

Drexler(R),Fahy(R),Küchler(M),Wagner(KC),Ree… Pancreatology 2021-01-00

...TEAD4 was evaluated with the immunoreactive score (IRS) by immunohistochemistry (IHC) using paraffin-embedded tissue. Re...

Analysis of transcription factors in accessible open chromatin in the 18-trisom…

Qiu(XF),Tang(D),Yu(HY),Liao(QY),Hu(ZY),Zhou(… Yi Chuan 2021-01-20

...TEAD4, Twist2) were confirmed using real-time quantitative fluorescence PCR. In conjunction with information from the li...

Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung can…

Adi Harel(S),Bossel Ben-Moshe(N),Aylon(Y),Bu… Cell Death Differ 2015-08-00

...TEAD4 mRNA was confirmed as a direct target of miR-512; likewise, miR-373 was found to target RelA and PIK3CA mRNA direc...

Novel Allosteric Effectors Targeting Human Transcription Factor TEAD.

Ibrahim(MT),Verkhivker(GM),Misra(J),Tao(P) Int J Mol Sci 2023-05-19

...TEAD4 and YAP1 domains indicated by the relative free energy perturbation to original molecules. Phe229, Thr332, Ile374,...

Aberrant activation of epigenetic BRD9-DGAT1 axis promotes lipid droplets depos…

Zhu(X),Wen(Z),Wu(J),Chen(S),Xu(R),Wang(B),Zh… Cell Death Dis 2026-04-14

...TEAD4 complex bound to the BRD9 promoter to elevate its levels. Integrated CUT&Tag-seq and RNA-seq analyses revealed DGA...

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