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Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.

Tsai(Ming-Feng),Jiang(Dawei),Zhao(Linlin),... J Gen Physiol 2014-08-15

...Letm1 protein in liposomes. Using Ca(2+) fluorophore and (45)Ca(2+)-based assays, we demonstrate directly that Letm1 is ...

Reliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ ...

Hajnóczky(György),Booth(David),Csordás(Gyö... Curr Opin Cell Biol 2014-11-13

...LETM1 and mitochondrial solute carriers. Recently, these proteins have triggered much interest and were described in rep...

Unusual 4p16.3 deletions suggest an additional chromosome region for the Wolf...

Zollino(Marcella),Orteschi(Daniela),Ruiter... Epilepsia 2014-08-13

...LETM1 and CPLX1. Direct sequencing of LETM1.,Three unusual 4p16.3 deletions were detected by array-CGH in absence of a o...

Prefrontal cortical and striatal transcriptional responses to the reinforcing...

dela Peña(Ike),Kim(Hee Jin),Sohn(Aeree),Ki... Behav Brain Funct 2014-09-19

...Letm1, Uqcrc2), and ubiquitin-mediated proteolysis (Nedd4, Usp27x, Ube2d2).,Together, these changes indicate methylpheni...

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby l...

De Marchi(Umberto),Santo-Domingo(Jaime),Ca... J Biol Chem 2014-10-06

...LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) were proposed to exchange Ca(2+) against Na(+) or H(+)...

Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) tra...

Mühling(Tobias),Duda(Johanna),Weishaupt(Jo... Front Cell Neurosci 2014-12-02

...Letm1, and UCP2 in remaining hMNs from endstage SOD1(G93A) mice. These higher expression-levels of mitochondrial Ca(2+) ...

LETM proteins play a role in the accumulation of mitochondrially encoded prot...

Zhang(Botao),Carrie(Chris),Ivanova(Aneta),... J Biol Chem 2013-02-12

...letm1 and Atletm2, together is lethal. Plants that are hemizygous for AtLETM2 and homozygous for Atletm1 (letm1(-/-) LET...

Trypanosome Letm1 protein is essential for mitochondrial potassium homeostasi...

Hashimi(Hassan),McDonald(Lindsay),Stríbrná... J Biol Chem 2013-12-17

...Letm1 in the highly diverged protist and significant pathogen, Trypanosoma brucei. We demonstrate that Letm1 is involved...

Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras1...

Shin(J-Y),Chung(Y-S),Kang(B),Jiang(H-L),Yu... Cancer Gene Ther 2013-08-29

...LETM1 as a binding partner of CTMP, LETM1-2A-CTMP downregulated the Akt1 pathway at both Ser473 and Thr308 sites of phos...

Mitochondria and plasma membrane Ca2+-ATPase control presynaptic Ca2+ clearan...

Shutov(Leonid P),Kim(Man-Su),Houlihan(Patr... J Physiol 2013-12-05

...Letm1 and NCLX. Collectively, this work identifies PMCA and mitochondria as the major regulators of presynaptic Ca(2+) s...

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