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Ral GTPases in tumorigenesis: emerging from the shadows.

Kashatus(David F) Exp Cell Res 2013-10-25

...RalB, remains the most poorly understood. This review will focus on key developments in our understanding of Ral biology...

Depletion of K-Ras promotes proteasome degradation of survivin.

Tecleab(Awet),Sebti(Saïd M) Cell Cycle 2013-08-01

...RalB, but not Raf-1, Akt1 and Akt2, decreases survivin levels, suggesting that K-Ras may regulate survivin stability thr...

The deubiquitylase USP33 discriminates between RALB functions in autophagy an...

Simicek(Michal),Lievens(Sam),Laga(Mathias)... Nat Cell Biol 2013-12-17

...RALB-positive vesicles. Deubiquitylated RALB promotes the assembly of the RALB-EXO84-beclin-1 complexes driving autophag...

Identification of a novel prenyl and palmitoyl modification at the CaaX motif...

Nishimura(Akiyuki),Linder(Maurine E) Mol Cell Biol 2013-07-30

...RalB and the phosphatase PRL-3, proteins terminating in a CCaX motif. The differentially modified forms of bCdc42 displa...

Dual effects of Ral-activated pathways on p27 localization and TGF-β signalin...

Tazat(Keren),Harsat(Meirav),Goldshmid-Shag... Mol Biol Cell 2013-12-17

...RalBP1 and phospholipase D1 (PLD1). Because RalA and RalB are equally effective in mislocalizing both murine and human p...

The role of membrane-trafficking small GTPases in the regulation of autophagy...

Bento(Carla F),Puri(Claudia),Moreau(Kevin)... J Cell Sci 2013-10-29

...RalB GTPases) and discusses their putative roles in the regulation of autophagosome formation, autophagosome-dependent e...

RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventric...

Rifki(Oktay F),Bodemann(Brian O),Battiprol... J Mol Cell Cardiol 2013-10-29

...RalB knockdown; however, activation of autophagy was suppressed only in NRCMs depleted of RalB, implicating RalB as bein...

Down-regulation of RalBP1 expression reduces seizure threshold and synaptic i...

Bae(Young-Soo),Chung(Woosuk),Han(Kihoon),P... Biochem Biophys Res Commun 2013-06-04

...RalBP1, a downstream effector of the small GTPases RalA and RalB, lowers the seizure threshold in mice. The intraperiton...

The RalB small GTPase mediates formation of invadopodia through a GTPase-acti...

Neel(Nicole F),Rossman(Kent L),Martin(Timo... Mol Cell Biol 2012-06-29

...RalB than on RalA. Surprisingly, RalB-mediated invadopodium formation was dependent on RalBP1/RLIP76 but not Sec5 and Ex...

Activation of autophagy by inflammatory signals limits IL-1β production by ta...

Shi(Chong-Shan),Shenderov(Kevin),Huang(Nin... Nat Immunol 2012-04-04

...RalB and autophagosome formation. The induction of autophagy did not depend on the adaptor ASC or capase-1 but was depen...

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