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Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and...

Norden(Pieter R),Kim(Dae Joong),Barry(Davi... PLoS One 2016-07-26

...Rap1b that act in conjunction with Cdc42 as well as the key downstream effectors, IQGAP1, MRCKβ, beta-Pix, GIT1, and Ras...

SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion thro...

Côte(Marjorie),Fos(Camille),Canonigo-Balan... J Cell Sci 2016-09-09

...Rap1B). This interaction has been further shown to facilitate the interdependent recruitment of Rap1 and SLAT to the T c...

Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibit...

Wang(Haibo),Han(Xiaokun),Bretz(Colin A),Be... Mol Ther Methods Clin Dev 2016-09-08

...Rap1b-deficient mice. Six-week-old mice that received subretinal control (scAAV2-Con) or constitutively active Rap1a (sc...

MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasio...

Peng(Hui),Luo(Jun),Hao(Hu),Hu(Jun),Xie(Sha... Oncol Rep 2015-01-12

...RAP1B, whereas miR-100 silencing upregulated the expression of the reporter gene. Furthermore, we also detected that RAP...

The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck c...

Banerjee(Rajat),Van Tubergen(Elizabeth A),... Mol Cancer Ther 2015-01-02

...RAP1B, thereby inducing p38-mediated inactivation of tristetraprolin (TTP), which functions to destabilize cytokine tran...

The structure and conformational switching of Rap1B.

Noguchi(Hiroki),Ikegami(Takahisa),Nagadoi(... Biochem Biophys Res Commun 2015-08-11

Rap1B is a small GTPase involved in the regulation of numerous cellular processes including synaptic plasticity, one of ...

Leukocyte transcellular diapedesis: Rap1b is in control.

Filippi(Marie-Dominique) Tissue Barriers 2015-10-09

...Rap1b GTPase limits neutrophil transcellular migration. Rap1b restrains transcellular migration by suppressing Akt-drive...

Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer ...

Lin(Kai-Ti),Yeh(Yu-Ming),Chuang(Chi-Mu),Ya... Nat Commun 2015-12-08

...Rap1B, which result in the reduction of integrin-mediated focal adhesion formation, inhibition of ovarian cancer cell mi...

Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polariz...

Muñoz-Llancao(Pablo),Henríquez(Daniel R),W... J Neurosci 2015-11-05

...Rap1b activation. Moreover, 8-pCPT-treated neurons expressed ankyrin G and other markers of mature axons such as synapto...

RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.

Bögershausen(Nina),Tsai(I-Chun),Pohl(Esthe... J Clin Invest 2015-11-25

...RAP1B in a second individual with a KS-like phenotype. We elucidated a genetic and functional interaction between the re...

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