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Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synerg...

Devlin(Jennifer R),Hannan(Katherine M),Hei... Cancer Discov 2016-10-13

...RPL5. Thus, targeting the network controlling the synthesis and function of ribosomes at multiple points provides a pote...

Growth inhibitory effects of large subunit ribosomal proteins in melanoma.

Kardos(Gregory R),Dai(Mu-Shui),Robertson(G... Pigment Cell Melanoma Res 2016-05-16

...RPL5 and RPL11 binding to and preventing MDM2 from targeting p53 for degradation. The consequence was p53-dependent cell...

Are Synonymous Substitutions in Flowering Plant Mitochondria Neutral?

Wynn(Emily L),Christensen(Alan C) J Mol Evol 2016-08-01

...rpl5 in most plant mitochondrial genomes, but in some genomes, rps14 has been duplicated to the nucleus leaving a pseudo...

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic i...

Kim(Tae-Hyung),Leslie(Patrick),Zhang(Yanping) Oncotarget 2015-02-21

...RPL5 and RPL11 are the most studied and RPL11 appears to have the most significant role in p53 regulation. Considering t...

The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis.

Kharde(Satyavati),Calviño(Fabiola R),Gumie... Nucleic Acids Res 2015-11-24

...RpL5 and RpL11 is recruited at an early stage, but has to rearrange during maturation of the pre-60S ribosomal subunit. ...

Chaperoning 5S RNA assembly.

Madru(Clément),Lebaron(Simon),Blaud(Magali... Genes Dev 2015-09-21

...Rpl5/uL18 and Rpl11/uL5, prior to its incorporation into preribosomes. In mammals, the 5S RNP is also a central regulato...

The RNA recognition motif of NIFK is required for rRNA maturation during cell...

Pan(Wen-An),Tsai(Hsin-Yue),Wang(Shun-Chang... RNA Biol 2015-12-17

...RPL5/RPL11-mediated nucleolar stress. Mechanistically it is the consequence of impaired maturation of 28S and 5.8S rRNA ...

Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome bioge...

Asano(Nozomi),Kato(Koji),Nakamura(Akiyoshi... Nucleic Acids Res 2015-07-31

...RpL5 and RpL11) to the 90S ribosome precursor and subsequent 27SB pre-rRNA processing. Here we present the crystal struc...

Clinical and genomic heterogeneity of Diamond Blackfan anemia in the Russian ...

Smetanina(Natalia S),Mersiyanova(Irina V),... Pediatr Blood Cancer 2015-10-13

...RPL5, RPL11, RPL35a, and GATA1.,Severe anemia presented before 8 months of age in all 77 patients; before 2 months in 61...

Perturbation of ribosome biogenesis drives cells into senescence through 5S R...

Nishimura(Kazuho),Kumazawa(Takuya),Kuroda(... Cell Rep 2015-11-25

The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation...

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