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CRISPR-mediated editing of cis-regulatory elements in early mouse embryos: a to…

Driscoll(CS),Kim(J),Knott(JG) Reproduction 2026-05-08

...Sox2 expression in 2-cell embryos required TFAP2C motifs located within the Sox2 proximal promoter. CRISPR-mediated edit...

Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells.

Yang(Q),Padilla-Galvez(M),Uhl(S),Eggenberger… bioRxiv 2026-03-27

...SOX2 and OCT4. Together, our findings support a model in which pluripotency factors regulate intrinsic immune gene expre...

Dose-resolved control of somatic reprogramming by Rora.

Wang(H),Li(Y),Yin(C),Zhang(Z),Wang(Y),Li(Y),… Stem Cell Reports 2026-04-14

...SOX2) reprogramming of mouse fibroblasts and identified the ROR subfamily as enhancers. Focusing on Rora, we uncovered a...

LIF signaling pathway regulates the heterogeneous Sox2 transcriptional dynamics…

Jin(G),Porello(EAL),Zhang(J),Vidal(JA),Lim(B) Sci Rep 2026-04-03

...Sox2 expression, suggesting a strong correlation between Sox2 levels and pluripotency maintenance. Additionally, Sox2 ex...

Ythdf2/Setd1b regulatory axis is essential for cerebellar development through r…

Ren(X),Jiang(J),Hu(X),Zhang(M),Li(J),Lu(J),X… Mol Psychiatry 2026-08-00

...Sox2, Nestin and Pax6 were markedly reduced, whereas markers of neuronal differentiation such as Tuj1 and Skor2 were inc...

Endogenous Sox2 expression is essential for Atoh1-induced hair cell addition an…

Yang(YT),Guo(JY),Xu(JY),Su(W),Hao(MY),Zhang(… Neuroscience 2026-06-22

...Sox2 knockdown attenuated the effects. In the diphtheria-toxin-injured adult utricle, Sox2 downregulation similarly weak...

ARHGEF26 Maintains SOX2 Stability by Inhibiting Ubiquitination to Enhance Gliob…

Chen(XQ),Qin(ZY),Li(ZB),Huang(JF),Hou(NN),Fu… Lab Invest 2026-05-00

...SOX2 by reducing its K48-linked polyubiquitination and subsequent proteasomal degradation. Our findings reveal a novel r...

Sex determining region Y box protein 2 (SOX2) expression, alteration, regulatio…

Jiang(X),Zheng(M),Zhang(L),Xu(D),Cheng(J),De… Discov Oncol 2026-04-06

...SOX2 mRNA levels were unchanged, whereas SOX2 protein levels were decreased. High SOX2 expression was significantly asso...

Dual suppression of stemness and redox adaptation in glioblastoma through filag…

Tran(HY),Sharma(R),Lin(HY),Yeh(TY),Shen(CJ),… J Biomed Sci 2026-04-06

...SOX2, 1.8-fold) and enhanced TMZ resistance, whereas cp8 treatment reduced MGMT protein expression by 68% and significan...

Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural …

Wang(L),Liu(Q),Zhang(Z),Yang(S),Tang(J),Pan(… Signal Transduct Target Ther 2026-04-07

...SOX2, and c-Jun) in PNI regions. Moreover, PTGES was more highly expressed in the central region of the PNI than in the ...

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