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Common variants at VRK2 and TCF4 conferring risk of schizophrenia.

Steinberg(Stacy),de Jong(Simone),,Andreass... Hum Mol Genet 2012-01-23

...VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) a...

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

Vázquez-Cedeira(Marta),Barcia-Sanjurjo(Iri... PLoS One 2011-12-27

...VRK2 and B1R. VRK1 is more sensitive to staurosporine, RO-31-8220 and TDZD8. VRK2 is more sensitive to roscovitine, RO 3...

NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the ...

Shin(Joon),Chakraborty(Goutam),Bharatham(N... J Biol Chem 2011-08-30

...VRK2 and VRK3) have been determined previously. However, the structure of VRK1, the most extensively studied and constit...

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correl...

Fernández(Isabel F),Blanco(Sandra),Lozano(... Mol Cell Biol 2010-11-15

...VRK2 level, suggesting a role for VRK2A in ErbB2-MAPK signaling. Thus, VRK2 downregulation in carcinomas permits signal ...

Further characterization of microdeletion syndrome involving 2p15-p16.1.

Félix(Têmis Maria),Petrin(Aline Lourenço),... Am J Med Genet A 2010-11-16

...VRK2 gene that had been speculated to have a role in cortical dysplasia. However, the association of the VRK2 gene with ...

Functional disruption of the moloney murine leukemia virus preintegration com...

Suzuki(Yasutsugu),Ogawa(Kanako),Koyanagi(Y... J Biol Chem 2010-09-14

...VRK2, which catalyze hyperphosphorylation of BAF, could abolish PIC function. We also found that treatment of PICs with ...

Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1...

Sanz-García(Marta),López-Sánchez(Inmaculad... Mol Cell Proteomics 2009-01-28

...VRK2 kinase activity, which may vary in different subcellular localizations generating an asymmetric intracellular distr...

Genes associated with an effective host response by Chinook salmon to Renibac...

Rhodes(Linda D),Wallis(Steviebrooke),Demlo... Dev Comp Immunol 2009-02-23

...VRK2 were upregulated in fish exposed to MT239, but downregulated or unchanged in fish exposed to 33209. A second group ...

Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highl...

Scheeff(Eric D),Eswaran(Jeyanthy),Bunkoczi... Structure 2009-03-06

...VRK2. Profound changes to the active site region underlie the loss of catalytic activity, and VRK3 cannot bind ATP becau...

The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downr...

Valbuena(Alberto),Blanco(Sandra),Vega(Fran... PLoS One 2008-10-21

...VRK2 protein.,Specific p53-dependent effects are determined by the availability and ratios of its transcriptional cofact...

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