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Culture medium and cell density impact gene expression in normal skin and abn...

McFarland(Kevin L),Glaser(Kathryn),Hahn(Je... J Burn Care Res 2011-11-23

...COL1A2) and matrix metalloproteinase 3 (MMP3) and lower levels of MMP1 were observed in all cell strains cultured in sta...

Allele-specific gene silencing in osteogenesis imperfecta.

Ljunggren(Osten),Lindahl(Katarina),Rubin(C... Endocr Dev 2011-12-20

...COL1A2, respectively. The patients suffer from bone fragility, and the severity can range from mild, with fractures in t...

[Genome array on differentially expressed genes of muscle tissue in intact ma...

Zhang(Ying-Ying),Zan(Lin-Sen),Wang(Hong-Ba... Yi Chuan 2011-05-20

...COL1A2, SPP1, FBN1, MMP2, ECM1, MYH3, MYH8, S100A4, ASPN, CFD etc were considered as the most important pathways and gen...

Genotype-phenotype correlations in autosomal dominant osteogenesis imperfecta...

Ben Amor(I Mouna),Glorieux(Francis H),Rauc... J Osteoporos 2011-11-10

...COL1A2, the genes that encode the two collagen type I alpha chains. Here we describe genotype-phenotype correlations in ...

Attenuation of expression of extracellular matrix genes with siRNAs to Sparc ...

Wang(J C),Sonnylal(S),Arnett(F C),De Cromb... Int J Immunopathol Pharmaco... 2011-12-02

...Col1a2 gene (Col1a2-CTGF) recapitulate multiorgan fibrosis similar to fibrosis observed in Scleroderma (SSc). In this st...

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling n...

Nakerakanti(Sashidhar S),Bujor(Andreea M),... PLoS One 2011-10-13

...COL1A2 promoter, however CCN2 was a weak inducer of collagen protein levels. CCN2 stimulation of collagen was dose-depen...

Suppression of hepatic stellate cell activation by microRNA-29b.

Sekiya(Yumiko),Ogawa(Tomohiro),Yoshizato(K... Biochem Biophys Res Commun 2011-10-14

...Col1a2 mRNAs and additionally blunted the increased expression of α-SMA, DDR2, FN1, ITGB1, and PDGFR-β, which are key ge...

Mutation characteristics in type I collagen genes in Chinese patients with os...

Yang(Z),Ke(Z F),Zeng(C),Wang(Z),Shi(H J),W... Genet Mol Res 2011-05-26

Osteogenesis imperfecta is normally caused by an autosomal dominant mutation in the type I collagen genes COL1A1 and COL...

Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a...

Kaneko(Hiroshi),Kitoh(Hiroshi),Matsuura(To... Hum Genet 2011-12-08

...COL1A2. We identified a dominant missense mutation, c.3235G>A in COL1A1 exon 45 predicting p.G1079S, in a Japanese famil...

Type 1 collagenopathy presenting with a Russell-Silver phenotype.

Parker(Michael J),Deshpande(Charulata),Ran... Am J Med Genet A 2011-09-20

...COL1A2 genes, respectively; quantitative or qualitative defects in type I collagen synthesis usually manifest as types o...

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