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Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) convention...

Grajales-Reyes(Gary E),Iwata(Arifumi),Albr... Nat Immunol 2015-09-16

...Batf3. However, after specification of pre-CD8 DCs, autoactivation of Irf8 became Batf3 dependent at a CD8α(+) cDC-speci...

Discovery of six new susceptibility loci and analysis of pleiotropic effects ...

Liu(Hong),Irwanto(Astrid),Fu(Xi'an),Yu(Gon... Nat Genet 2015-04-28

...BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. A systematic evaluation of pleiotropic effects d...

CD103+ dendritic cells producing interleukin-12 in anticancer immunosurveilla...

Zitvogel(Laurence),Kroemer(Guido) Cancer Cell 2015-02-09

...Batf3 and Irf8, and interleukin-12 production.

A new paradigm for tumor immune escape: β-catenin-driven immune exclusion.

Spranger(Stefani),Gajewski(Thomas F) J Immunother Cancer 2015-09-18

...Batf3-lineage dendritic cell recruitment. Hence, tumor cell-intrinsic activation of β-catenin is the first oncogenic pat...

Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ.

Krueger(Peter D),Kim(Taeg S),Sung(Sun-Sang... J Immunol 2015-06-08

...Batf3(-/-) mouse, which lacks CD8α(+) and CD103(+) DCs in the liver, results in a 3-fold reduction in the proliferative ...

Batf2/Irf1 induces inflammatory responses in classically activated macrophage...

Roy(Sugata),Guler(Reto),Parihar(Suraj P),S... J Immunol 2015-08-20

...Batf3 have been shown to play essential roles in dendritic cell, T cell, and B cell development and regulation. Batf2 wa...

Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated c...

Zhang(Yi),Chen(Guo),Liu(Zuqiang),Tian(Shen... J Immunol 2015-08-20

...Batf3(+) DC, pDC, and CD8(+) T cells. CD103(+) DC from the skin/tumor draining lymph nodes of the immunized mice appeare...

Selective and efficient generation of functional Batf3-dependent CD103+ dendr...

Mayer(Christian Thomas),Ghorbani(Peyman),N... Blood 2015-01-12

...Batf3-dependent CD103(+) DCs efficiently enter lymph nodes and cross-present antigens, rendering this conserved DC subse...

Batf3-independent langerin- CX3CR1- CD8α+ splenic DCs represent a precursor f...

Petersen(Troels R),Knight(Deborah A),Tang(... J Leukoc Biol 2015-01-30

...Batf3(-/-) mice. We conclude that the classical attributes of CD8α(+) DC are confined primarily to the langerin(+) CX(3)...

Dissecting the tumor myeloid compartment reveals rare activating antigen-pres...

Broz(Miranda L),Binnewies(Mikhail),Boldaji... Cancer Cell 2015-02-09

...Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines. Regressing tumors have higher proportions o...

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