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Quantitative proteomics of transporter expression in brain capillary endothel...

Agarwal(Sagar),Uchida(Yasuo),Mittapalli(Ra... Drug Metab Dispos 2013-03-08

...Bcrp1(-/-) mice. Likewise, Bcrp expression was not significantly different between the wild-type and Mdr1a/b(-/-) mice. ...

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein a...

Bankstahl(Jens P),Bankstahl(Marion),Römerm... Drug Metab Dispos 2013-11-04

...Bcrp1((-/-)) mice, respectively, but remained unchanged in Mdr1a/b((-/-))Bcrp1((-/-)) mice. Activity uptake of [(11)C]TQ...

Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E)...

Mittapalli(Rajendar K),Vaidhyanathan(Shrut... J Pharmacol Exp Ther 2013-06-18

...Bcrp1(-/-) mice to 0.42. Dabrafenib plasma exposure was ∼2-fold greater in Mdr1 a/b(-/-)Bcrp1(-/-) mice as compared with...

Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast canc...

Rong(Zhihui),Xu(Yanjiao),Zhang(Chengliang)... Life Sci 2013-03-26

...Bcrp1 knockout mice and wild-type mice.,BCRP inhibitor Ko143 (50 μM and 100 μM) significantly increased the intestinal a...

Saturable active efflux by p-glycoprotein and breast cancer resistance protei...

Sane(Ramola),Agarwal(Sagar),Mittapalli(Raj... J Pharmacol Exp Ther 2013-05-16

...Bcrp1(-/-), and Mdr1a/b(-/-)Bcrp1(-/-) mice. Initially, the mice were administered 2.5 mg/kg of elacridar intravenously,...

In vitro drug response and efflux transporters associated with drug resistanc...

Veringa(Susanna J E),Biesmans(Dennis),van ... PLoS One 2013-11-26

...BCRP1, and MRP1 in glioma cultures and their corresponding tumor tissues. Results indicate the presence of P-gp, MRP1 an...

Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresis...

Shimura(T),Noma(N),Oikawa(T),Ochiai(Y),Kak... Oncogenesis 2013-04-04

...BCRP1), and high tumorigenic potential after transplantation into nude mice. The advantage of our isolated CSCs is that ...

Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/A...

Hosomi(Atsushi),Nakanishi(Takeo),Fujita(Ta... PLoS One 2012-07-31

...Bcrp1 knockout mice exhibited significantly decreased intestinal secretion and an increased plasma concentration of uric...

Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resi...

Agarwal(Sagar),Elmquist(William F) Mol Pharm 2012-07-05

...Bcrp1(-/-) mice and 2.5-fold in the Mdr1a/1b(-/-)Bcrp1(-/-) mice. Clearance out of brain when P-gp was absent did not ch...

Use of the cassette-dosing approach to assess brain penetration in drug disco...

Liu(Xingrong),Ding(Xiao),Deshmukh(Gauri),L... Drug Metab Dispos 2012-08-23

...Bcrp1(-/-), and Mdr1a/1b(-/-)/Bcrp1(-/-) mice at 1 to 3 mg/kg. The mice brain and plasma were collected at 0.25, 1, and ...

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