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Coordinated Interferon-γ/Tumor Necrosis Factor Axis Drives Selective Loss of Ac…

Bubeck(M),Penkert(KA),Limberger(H),Acera(MG)… Cell Mol Gastroenterol Hepatol 2026-06-12

...Casp8 deletion to dissect mechanisms of enteric glial cell activation and death. Ex vivo stimulation of sorted enteric g...

Anchusa azurea enhances cisplatin efficacy in oral and bone cancers through IL-…

Fahim(SA),El-Haddad(AE),Moustafa(RI),Ali(SO)… Sci Rep 2026-06-13

...Casp8 levels, cell cycle arrest, and enhanced autophagy. The TPC and TFC of AAME are 5.46 mgGAE/gE and 0.13 mgRE/gE resp...

Multi-omics and experimental evidence in human chondrocytes identify caspase-8 …

Mei(J),Wei(P),Schäfer(N),Ehrnsperger(M),John… Cell Commun Signal 2026-06-06

...CASP8 patterns, including senescence- but not inflammation-associated CASP8 elevation in naturally aged cartilage, no co...

Mechanistic evaluation of niosomal Rhoifolin in antileishmanial therapy and its…

Kenzerki(RE),Karamian(M),Sharifi(I),Pardakht… Sci Rep 2026-06-06

...CASP8, and Bax, along with reduced Bcl-2 expression. Immunological analyses also demonstrated macrophage polarization to...

Proteasomal inhibition compromises microvascular integrity via distinct effects…

Sawant(P),Wolf(H),Mathew(A),Bensalel(J),Gall… Front Immunol None

...CASP8 (mediator of extrinsic-apoptosis) and CASP3 (terminal executioner of apoptosis). BTZ-treated HPMECs significantly ...

Research on the mechanism of Duhuo in treating intervertebral disc degeneration…

Yan(Q),Liu(F),Xu(Z),Zhang(C),Yang(L),Wu(X),J… Medicine (Baltimore) 2026-06-05

...CASP8, and CASP9. Although Duhuo alleviates inflammation and delays IVDD, its molecular mechanism remains unclear. We us...

Comprehensive metabolomic profiling of Egyptian Salvia species reveals promisin…

Hamed(AR),Ali(SK),Abdel-Halim(SA),Bata(SM),H… Sci Rep 2026-06-09

...CASP8, PARP1, iNOS, EGFR, PPARG, AKR1C isoforms, and NQO1) linked to inflammatory and antioxidant signaling. Docking ana...

Integrating network pharmacology, molecular docking and experimental verificati…

Yang(M),Ren(H),Xu(P),Ren(X),Aihaiti(Y),Wen(P… Front Immunol None

...CASP8) were selected. PIC showed stable binding to all hub genes (affinities: -5.6 to -7.8 kcal/mol). ConnectivityMap su...

Role of Programmed Cell Death Pathways in Mediating Epithelial Wound Healing an…

Gao(N),Yu(FX) Invest Ophthalmol Vis Sci 2026-05-01

...Casp8 upregulation was blunted, whereas RIPK3 upregulation was enhanced. At the tissue level, cleaved caspase-3 (c-Casp3...

XBP1 gene silencing augments quercetin-induced apoptosis and anti-metastatic ac…

Akçaalan(S),Eroğlu Güneş(C),Kurar(E) 3 Biotech 2026-07-00

...CASP8 and CASP9, supporting a pro-apoptotic response. In addition, treatment-related changes were observed in EMT-associ...

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