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Fullerene derivatives induce premature senescence: a new toxicity paradigm or...

Gao(Jun),Wang(Hsing Lin),Shreve(Andrew),Iy... Toxicol Appl Pharmacol 2010-04-13

...HERC5 was noted. HERC5 is a ubiquitin ligase of the HERC family and is implicated to be involved in innate immune respon...

ISG15 and immune diseases.

Jeon(Young Joo),Yoo(Hee Min),Chung(Chin Ha... Biochim Biophys Acta 2010-05-11

...HERC5), catalyzes ISG15 conjugation (ISGylation) of a specific protein. These enzymes are unique among the cascade enzym...

Deletion of the Isg15 gene results in up-regulation of decidual cell survival...

Ashley(Ryan L),Henkes(Luiz E),Bouma(Gerrit... Endocrinology 2010-10-04

...HERC5, UBCH8) that coordinate the covalent conjugation of ISG15 to target proteins, as well as the gene that encodes the...

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis ...

Salajegheh(Mohammad),Kong(Sek Won),Pinkus(... Ann Neurol 2010-03-25

...HERC5 62-fold, and USP18 68-fold) compared with 99 non-DM samples. Combined analysis with publicly available microarray ...

Pediatric primary central nervous system germ cell tumors of different progno...

Wang(Hsei-Wei),Wu(Yu-Hsuan),Hsieh(Jui-Yu),... BMC Genomics 2010-05-03

...HERC5) within 4q13.3-4q28.3 were more abundant in germinomas.,Our results integrate molecular profiles with clinical obs...

Species-specific antagonism of host ISGylation by the influenza B virus NS1 p...

Versteeg(Gijs A),Hale(Benjamin G),van Bohe... J Virol 2010-05-04

...HerC5, but not human HerC6, has ISG15 E3 ligase activity and identify mouse HerC6 as a bona fide ISG15 E3 ligase. Furthe...

The ISG15 conjugation system broadly targets newly synthesized proteins: impl...

Durfee(Larissa A),Lyon(Nancy),Seo(Kyungwoo... Mol Cell 2010-06-29

...Herc5 is physically associated with polyribosomes. These results lead to a model for ISGylation in which Herc5 broadly m...

Expression phenotype changes of EBV-transformed lymphoblastoid cell lines dur...

Lee(J-E),Nam(H-Y),Shim(S-M),Bae(G-R),Han(B... Cell Prolif 2010-07-13

...HERC5 and miR-146a) and carcinogenesis-related genes (such as XAF1, TCL1A, PTPN13, CD38 and miR-146a) were differentiall...

Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 prot...

Tang(YuJie),Zhong(Gongxun),Zhu(Lianhui),Li... J Immunol 2010-07-19

...Herc5 could catalyze conjugation of ISG15 onto IAV-NS1 protein, the critical virulence factor of IAV. This modification ...

Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pat...

Hoffman(Aaron E),Zheng(Tongzhang),Ba(Yue),... BMC Cancer 2010-06-14

...HERC5 (Q < 0.001), MCM5 (Q = 0.042), PPP1R15A (Q < 0.001), SUMO1 (Q < 0.001), and UBA1 (Q = 0.023). However, no signific...

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