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The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain...

He(Jun),Kulkarni(Kiran),da Fonseca(Paula C... Structure 2012-06-29

...Rpn2 function to engage ubiquitin receptors. Rpn1 and Rpn2 are characterized by eleven tandem copies of a 35-40 amino ac...

RPN2 expression predicts response to docetaxel in oesophageal squamous cell c...

Kurashige(J),Watanabe(M),Iwatsuki(M),Kinos... Br J Cancer 2012-12-11

...RPN2-positive and RPN2-negative groups. We also studied susceptibility of RPN2-suppressed ESCC cells to docetaxel.,The R...

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes ...

Wiggins(Ceri M),Tsvetkov(Peter),Johnson(Ma... J Cell Sci 2011-06-13

...Rpn2 does not prevent BIM(EL) turnover in cells, and inhibition of the E3 ubiquitin ligase β-TrCP, which catalyses poly-...

Osmotic stress inhibits proteasome by p38 MAPK-dependent phosphorylation.

Lee(Seung-Hoon),Park(Yoon),Yoon(Sungjoo Ki... J Biol Chem 2011-02-09

...Rpn2 is the major phosphorylation site affected by p38 MAPK. The mutation T273A in Rpn2 blocked the proteasome inhibitio...

Chemotherapy dosing schedule influences drug resistance development in ovaria...

De Souza(Raquel),Zahedi(Payam),Badame(Rose... Mol Cancer Ther 2011-11-03

...rpn2, thoredoxin, and akt2. In both models, continuous docetaxel resulted in greater antitumor efficacy than 1×/wk or 3×...

Proteasome activator 200: the heat is on...

Savulescu(Anca F),Glickman(Michael H) Mol Cell Proteomics 2011-09-06

...Rpn2) alongside six ATPases (Rpt1-6), attaches to the same surface of the CP ring, and likewise, induces pore opening.

Multilocus sequence typing of oenological Saccharomyces cerevisiae strains.

Muñoz(Rosario),Gómez(Alicia),Robles(Virgin... Food Microbiol 2010-01-04

...RPN2, GLN4, and ALA1 genes were amplified by PCR from chromosomal DNA of 18 wine Saccharomyces cerevisiae strains. Ten p...

Proteasome subunits relocalize during human cytomegalovirus infection, and pr...

Tran(Karen),Mahr(Jeffrey A),Spector(Debora... J Virol 2010-04-02

...Rpn2, is specifically recruited into the viral DNA replication center. The relocalization of the subunits requires viral...

The 20S proteasome as an assembly platform for the 19S regulatory complex.

Hendil(Klavs B),Kriegenburg(Franziska),Tan... J Mol Biol 2009-11-12

...Rpn2, Rpn10, Rpn11, Rpn13, and Txnl1, attached to preexisting 20S proteasomes. This early assembly complex does not yet ...

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by m...

Kaneko(Takeumi),Hamazaki(Jun),Iemura(Shun-... Cell 2009-06-22

...Rpn2, where p28, S5b, and p27 regulate the associations between the modules. These chaperones dissociate before completi...

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