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The genetics of fat distribution.

Schleinitz(Dorit),Böttcher(Yvonne),Blüher(... Diabetologia 2015-01-29

...RSPO3 and CPEB4) strongly associated with FD. More accurate methods, including cardiometabolic imaging, for assessment o...

Genetic determinants of heel bone properties: genome-wide association meta-an...

Moayyeri(Alireza),Hsu(Yi-Hsiang),Karasik(D... Hum Mol Genet 2015-01-12

...RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we...

LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production...

Shaikh(Lalarukh Haris),Zhou(Junhua),Teo(Ad... J Clin Endocrinol Metab 2015-08-24

...RSPO3, was 5-fold up-regulated. In total, 18 genes associated with the Wnt pathway were greater than 2-fold up-regulated...

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promote...

Gong(X),Yi(J),Carmon(K S),Crumbley(C A),Xi... Oncogene 2015-11-25

...RSPO3, LGR4 or their signaling mediator IQGAP1 in lung cancer cell lines with Keap1 deficiency and high RSPO3-LGR4 expre...

RSPO fusion transcripts in colorectal cancer in Japanese population.

Shinmura(Kazuya),Kahyo(Tomoaki),Kato(Hisam... Mol Biol Rep 2015-10-29

...RSPO3 fusion transcripts using RT-PCR and subsequent sequencing analyses. Although the expression of EIF3E-RSPO2 and PTP...

R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagoni...

Rong(Xiaozhi),Chen(Chen),Zhou(Pin),Zhou(Yu... PLoS One 2015-10-13

...Rspo3 plays a negative role in regulating the zygotic Wnt/β-catenin signaling. Zebrafish Rspo3 has a unique domain struc...

LGR5/GPR49 is implicated in motor neuron specification in nervous system.

Song(Shao-jun),Mao(Xing-gang),Wang(Chao),H... Neurosci Lett 2015-07-06

...RSPO3) are specifically highly expressed in projection motor neurons in the spinal cord, brain stem and cerebral. Inhibi...

Computational biophysical, biochemical, and evolutionary signature of human R...

Sharma(Ashish Ranjan),Chakraborty(Chiranji... Biomed Res Int 2015-06-16

...Rspo3, four N-glycosylation sites were noted. All members are hydrophilic in nature and showed alike GRAVY values, appro...

Genome-wide association of body fat distribution in African ancestry populati...

Liu(Ching-Ti),Monda(Keri L),Taylor(Kira C)... PLoS Genet 2014-03-21

...RSPO3, ITPR2-SSPN). Further, we observed associations with metabolic traits: rs13389219 at GRB14 associated with HDL-cho...

Stroma provides an intestinal stem cell niche in the absence of epithelial W...

Kabiri(Zahra),Greicius(Gediminas),Madan(Ba... Development 2014-07-14

...Rspo3 support the growth of Porcn(Del) organoids ex vivo without RSPO1 supplementation. Conversely, increasing pharmacol...

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