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Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH i...

Wang(Tiehui),Gao(Qian),Nie(Pin),Secombes(C... Fish Shellfish Immunol 2010-11-23

...SOCS6, 7 and 9 expression. However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and LPS stimulation of pri...

Genomic organization and functional characterization of the promoter for the ...

Lai(Rai-Hua),Wang(Mei-Jung),Yang(Shung-Hau... Gene 2009-10-26

...SOCS6), and the characterization of the functional promoter region. The human SOCS6 gene, spanning 40 kb on chromosome 1...

Suppressors of cytokine-signaling proteins induce insulin resistance in the r...

Liu(Xuebin),Mameza(Marie G),Lee(Yun Sang),... Diabetes 2008-08-01

...SOCS6 or overexpressing SOCS1/SOCS3, and 5) oxidative stress and light-induced retinal degeneration models.,We show that...

Insulin receptor substrate 4 couples the leptin receptor to multiple signalin...

Wauman(Joris),De Smet(Anne-Sophie),Catteeu... Mol Endocrinol 2008-07-21

...SOCS6, and SOCS7 and thus can modulate LR signaling.

The nuclear localization of SOCS6 requires the N-terminal region and negative...

Hwang(Mi-Na),Min(Chan-Hee),Kim(Hyung Sik),... Biochem Biophys Res Commun 2007-08-23

...SOCS6 was localized in both the nucleus and cytoplasm. The localization of SOCS6 depended on amino acids 1-210 in the N-...

Increased SOCS6 stability with PMA requires its N-terminal region and the Erk...

Hwang(Mi-Na),Ha(Tae Hun),Park(Jongsun),Shi... Biochem Biophys Res Commun 2007-04-06

...SOCS6 with PMA did not generally occur in other proteins. The stability of SOCS6 depended on the N-terminal region conta...

Attenuation of leptin and insulin signaling by SOCS proteins.

Howard(Jane K),Flier(Jeffrey S) Trends Endocrinol Metab 2007-02-01

...SOCS6 and SOCS7).

Expression of SOCS1 and SOCS3 genes is differentially regulated in breast can...

Evans(M K),Yu(C-R),Lohani(A),Mahdi(R M),Li... Oncogene 2007-04-24

...SOCS6, SOCS7, CIS and/or SOCS1 genes in the human cancer cells. In MCF-7 and HCC1937 breast-cancer cells, transcription ...

Functional cross-modulation between SOCS proteins can stimulate cytokine sign...

Piessevaux(Julie),Lavens(Delphine),Montoye... J Biol Chem 2006-12-11

...SOCS6 and SOCS7. Our findings point to a unique regulatory role for SOCS2, SOCS6, and SOCS7 within the SOCS family and p...

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation...

Bayle(Julie),Lopez(Sophie),Iwaï(Kazuhiro),... FEBS Lett 2006-07-05

...SOCS6. The Ubl domain of HOIL-1 and the SH2 and Socs-box domains of SOCS6 are required for the interaction. HOIL-1 expre...

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