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Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell pro...

Kim(Nam-Yi),Lee(Hwa-Young),Lee(Chuhee) Int J Oncol 2016-03-21

...Tyro3 specific siRNAs, siAxl and siTyro3, respectively, suggesting that metformin might target Axl and Tyro3 RTKs to res...

Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apopto...

Sinha(Sutapa),Boysen(Justin),Nelson(Michae... Clin Cancer Res 2016-03-31

...Tyro3, but not MER. Of interest, Tyro3 remains as constitutively phosphorylated and forms a complex with Axl in CLL B ce...

TAM receptors support neural stem cell survival, proliferation and neuronal d...

Ji(Rui),Meng(Lingbin),Jiang(Xin),Cvm(Nares... PLoS One 2016-02-04

Tyro3, Axl and Mertk (TAM) receptor tyrosine kinases play multiple functional roles by either providing intrinsic trophi...

Mertk deficiency affects macrophage directional migration via disruption of c...

Tang(Yong),Wu(Shen),Liu(Qian),Xie(Jiayi),Z... PLoS One 2016-01-05

...Tyro3, Axl and Mertk (TAM) family of receptor tyrosine kinases, and plays a pivotal role in regulation of cytoskeletal r...

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses...

Vouri(Mikaella),An(Qian),Birt(Matthew),Pil... Oncotarget 2016-05-03

...Tyro3 receptors, as well as ligand-independent Axl signalling, to take place in GBM cells. In conclusion, small molecule...

Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling...

Miyamoto(Yuki),Torii(Tomohiro),Takada(Shuj... Mol Biol Cell 2016-08-03

...Tyro3 intracellular domain, and activity of Fyn is down-regulated in Tyro3-knockout mice, suggesting that Tyro3, acting ...

TAM receptor deficiency affects adult hippocampal neurogenesis.

Ji(Rui),Meng(Lingbin),Li(Qiutang),Lu(Qingx... Metab Brain Dis 2016-04-01

...Tyro3, Axl and Mertk (TAM) subfamily of receptor protein tyrosine kinases functions in cell growth, differentiation, sur...

Growth arrest-specific protein 6 protects against renal ischemia-reperfusion ...

Giangola(Matthew D),Yang(Weng-Lang),Rajaye... J Surg Res 2016-02-29

...Tyro3, Axl, Mer-family tyrosine kinase receptors, which modulate the inflammatory response and activate cell survival pa...

Tyro3 Modulates Mertk-Associated Retinal Degeneration.

Vollrath(Douglas),Yasumura(Douglas),Bencho... PLoS Genet 2016-06-01

...Tyro3, a paralog of Mertk. Tyro3 expression in the outer retina varies with modifier genotype in a manner characteristic...

Overexpression of Tyro3 and its implications on hepatocellular carcinoma prog...

Duan(Yan),Wong(Winnie),Chua(Sonja Courtney... Int J Oncol 2016-09-22

...Tyro3, a relatively uncharacterized member of the TAM (Tyro3, Axl and Mer) receptor family. The present study aimed to p...

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