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Can celecoxib affect P-glycoprotein-mediated drug efflux? A microPET study.

de Vries(EF),Doorduin(J),Vellinga(NA),van Wa… Nucl Med Biol 2008-05-00

...Pgp substrates. To clarify whether Pgp is involved in the sensitizing effect of celecoxib, we investigated in vivo wheth...

Broad-spectrum modulation of ATP-binding cassette transport proteins by the tax…

Minderman(H),Brooks(TA),O'Loughlin(KL),Ojima… Cancer Chemother Pharmacol 2004-05-00

...Pgp-expressing cells by virtue of modulation of Pgp-mediated transport. The synthetic taxane tRA96023 also modulates Pgp...

Role of multidrug resistance and its pharmacological modulation in acute myeloi…

List(AF) Leukemia 1996-06-00

...Pgp relates in part to variance in drug transport capacity. In Pgp expressing cells, capacity for drug extrusion is gove...

Subcellular detection and localization of the drug transporter P-glycoprotein i…

Molinari(A),Calcabrini(A),Meschini(S),String… Curr Protein Pept Sci 2002-12-00

...Pgp was found abnormally expressed on the plasma membrane of tumor cells with "classical" MDR phenotype. However, Pgp wa...

Modulation of doxorubicin concentration by cyclosporin A in brain and testicula…

Hughes(CS),Vaden(SL),Manaugh(CA),Price(GS),H… J Neurooncol 1998-03-00

...Pgp) is an inducible transmembrane protein that functions as an ATP-dependent efflux pump. Pgp is normally expressed in ...

Presence of classical multidrug resistance and P-glycoprotein expression in hum…

Kurowski(C),Berthold(F) Ann Oncol 1998-00-00

...Pgp blocker verapamil. Pgp expression was detected by immunocytochemistry in 14 out of 62 tumors (22.6%). No correlation...

Drug transport by reconstituted P-glycoprotein in proteoliposomes. Effect of su…

Lu(P),Liu(R),Sharom(FJ) Eur J Biochem 2001-03-00

...Pgp was collapsed by the addition of either the ATPase inhibitor, vanadate, or Pgp modulators. TMR transport by Pgp obey...

P-glycoprotein-mediated colchicine resistance in different cell lines correlate…

Druley(TE),Stein(WD),Ruth(A),Roninson(IB) Biochemistry 2001-04-10

...Pgp correlates with the Pgp density. Vinblastine induces a conformational change in Pgp, evidenced by increased reactivi...

PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug…

Walter(RB),Pirga(JL),Cronk(MR),Mayer(S),Appe… Blood 2005-11-15

...Pgp)-mediated drug efflux to chemosensitize cancer cells at least as well or better than the Pgp modulator, cyclosporine...

Multidrug transporters as drug targets.

Liang(XJ),Aszalos(A) Curr Drug Targets 2006-08-00

...Pgp. These three transporters, and especially Pgp, are often targets of drugs. Pgp can be an intentional or unintentiona...

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