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The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyros…

Howlett(C J),Bisson(S A),Resek(M E),Tigley(A… Biochem Biophys Res Commun 1999-05-11

...Hck phosphorylates Cbl in vitro and the interaction between Cbl and Hck is direct, requiring Hck's unique, SH3 and SH2 d...

Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's…

Mahajan(S),Ghosh(S),Sudbeck(E A),Zheng(Y),Do… J Biol Chem 1999-04-27

...HCK, epidermal growth factor receptor kinase, and insulin receptor kinase. In accordance with the anti-apoptotic functio...

The carboxyl-terminal domains of gp130-related cytokine receptors are necessary…

Ernst(M),Novak(U),Nicholson(S E),Layton(J E)… J Biol Chem 1999-04-27

...Hck kinase activity and suppress ES cell differentiation. Moreover, STAT3 antisense oligonucleotides impaired LIF-depend...

The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma…

Orlicek(S L),Hanke(J H),English(B K) Shock 1999-12-07

...hck, fgr, and lyn) in mice failed to demonstrate a requirement for these particular kinases in macrophage activation. We...

Activation of src tyrosine kinases by peroxynitrite.

Mallozzi(C),Di Stasi(A M),Minetti(M) FEBS Lett 1999-09-09

...hck and c-fgr) and bovine synaptosomes (lyn and fyn) was stimulated by treatment with 30-250 microM peroxynitrite. This ...

Cell volume-dependent regulation of L-selectin shedding in neutrophils. A role …

Rizoli(S B),Rotstein(O D),Kapus(A) J Biol Chem 1999-08-19

...Hck, Syk, and Pyk2, but prevention of their activation by the Src-family inhibitor PP1 failed to affect the L-selectin r...

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase…

Schindler(T),Sicheri(F),Pico(A),Gazit(A),Lev… Mol Cell 1999-06-17

...Hck has been determined at 2.0 A resolution, in complex with a specific pyrazolo pyrimidine-type inhibitor, PP1. The act...

SH2-kinase linker mutations release Hck tyrosine kinase and transforming activi…

Briggs(S D),Smithgall(T E) J Biol Chem 1999-10-07

...Hck with the human immunodeficiency virus type I Nef protein activates Hck tyrosine kinase and biological activities, su...

The cellular kinase binding motifs (PxxP and RR) in human immunodeficiency viru…

Tokunaga(K),Ikuta(K),Adachi(A),Matsuda(M),Ku… Virology 1999-06-15

...Hck and to a serine/threonine kinase, respectively. To address whether these cellular kinase binding motifs, PxxP and RR...

Phorbol ester-induced disruption of the CD4-Lck complex occurs within a deterge…

Parolini(I),Topa(S),Sorice(M),Pace(A),Ceddia… J Biol Chem 1999-06-17

...Hck, and Fyn), heterotrimeric G proteins, and gangliosides (GM1 and GM3). Human T lymphocytes have become a well establi...

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