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Pilocarpine-induced convulsive activity is limited by multidrug transporters at…

Römermann(K),Bankstahl(J P),Löscher(W),Banks… J Pharmacol Exp Ther 2015-05-26

...PGP-deficient mice. Brain-plasma ratios were higher in mice lacking PGP or PGP and BCRP, which was also observed after p...

Proline-containing peptides-New insight and implications: A Review.

Misiura(M),Miltyk(W) Biofactors 2019-11-00

...PGP), cyclic Gly-Pro (cGP), as well as PGP derivatives, for example, N-acetylated PGP (N-a-PGP) and N-methylated PGP (N-...

The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated…

Sigdel(KP),Wilt(LA),Marsh(BP),Roberts(AG),Ki… Biochem Pharmacol 2018-00-00

...Pgp transporter molecules in a lipid bilayer under physiological pH and ambient temperature. Analysis of the Pgp AFM ima...

(+/-)-Borneol Reverses Mitoxantrone Resistance against P-Glycoprotein.

Yang(R),Chen(Z),Xie(F),Xie(M),Liu(N),Su(Z),G… J Chem Inf Model 2021-00-25

...Pgp) is a main factor contributing to multidrug resistance and the consequent failure of chemotherapy. Overcoming Pgp ef...

Drug binding and nucleotide hydrolyzability are essential requirements in the v…

Rao(US) Biochemistry 1998-10-20

...Pgp) mediates drug transport utilizing the energy released from ATP hydrolysis. However, the mechanism by which Pgp coup...

Characterization of the ATPase activity of P-glycoprotein from multidrug-resist…

Sharom(FJ),Yu(X),Chu(JW),Doige(CA) Biochem J 1995-06-01

...Pgp ATPase was relatively selective for adenine nucleotides. Several phospholipids stimulated Pgp ATPase activity in a d...

P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells express…

Hochman(JH),Chiba(M),Yamazaki(M),Tang(C),Lin… J Pharmacol Exp Ther 2001-07-00

...Pgp)-ATPase activity in a concentration-dependent manner. This stimulation was inhibited by the Pgp-specific monoclonal ...

Discordant P-glycoprotein antigen expression and transport function in acute my…

Xie(XY),Robb(D),Chow(S),Hedley(DW) Leukemia 1995-11-00

...Pgp inhibitor cyclosporin A (CsA) on the cellular accumulation of daunorubicin, and Pgp antigen expression by surface im...

Characterization of the ATPase activity of purified Chinese hamster P-glycoprot…

Urbatsch(IL),al-Shawi(MK),Senior(AE) Biochemistry 1994-06-14

...Pgp from plasma membranes and chromatography on Reactive Red 120 agarose. The purified Pgp displayed substantial verapam...

P-glycoprotein is positively correlated with p53 protein accumulation in human …

Oka(M),Kounoura(K),Narasaki(F),Sakamoto(A),F… Jpn J Cancer Res 1997-08-00

...Pgp were co-expressed in a significant number of samples (P < 0.002). There was no relationship between Pgp or p53 prote...

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