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The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary a…

Chang(C P),de Vivo(I),Cleary(M L) Mol Cell Biol 1997-01-22

...Pbx1 are necessary for oncogenesis, but the Pbx1 homeodomain is dispensable and the required portion of Pbx1 has not bee...

A novel fibroblast growth factor gene expressed in the developing nervous syste…

McWhirter(J R),Goulding(M),Weiner(J A),Chun(… Development 1997-10-28

...Pbx1 fusion protein should therefore activate transcription of genes normally regulated by Pbx1. We have used the subtra...

mirror encodes a novel PBX-class homeoprotein that functions in the definition …

McNeill(H),Yang(C H),Brodsky(M),Ungos(J),Sim… Genes Dev 1997-05-29

...PBX1. mrr is similar to the Iroquois genes ara and caup and is located adjacent to them in this recently described homeo...

The Pbx family of proteins is strongly upregulated by a post-transcriptional me…

Knoepfler(P S),Kamps(M P) Mech Dev 1997-07-29

...Pbx1, Pbx2, and Pbx3 exhibit different profiles of upregulation, suggesting possible functional divergence. The parallel...

Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic cells by a p53…

Smith(K S),Jacobs(Y),Chang(C P),Cleary(M L) Oncogene 1997-07-17

...Pbx1 results from fusion of the E2A and PBX1 genes following t(1;19) chromosomal translocations in B cell precursor acut...

Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chr…

Rambaldi(A),Attuati(V),Bassan(R),Neonato(M G… Leuk Lymphoma 1997-06-05

...PBX1 transcripts generated by the t(1;19) were found in only two of the 87 B-precursor ALL analyzed. The presented resul...

Meis proteins are major in vivo DNA binding partners for wild-type but not chim…

Chang(C P),Jacobs(Y),Nakamura(T),Jenkins(N A… Mol Cell Biol 1997-10-23

...Pbx1 is unable to bind DNA with Meis1, due to the deletion of amino-terminal Pbx1 sequences following fusion with E2a. W...

The majority of myeloid-antigen-positive (My+) childhood B-cell precursor acute…

Baruchel(A),Cayuela(J M),Ballerini(P),Landma… Br J Haematol 1997-12-09

...PBX1, MLL-AF4, BCR-ABL expression and an immunophenotypic study of CD13/CD33 myeloid antigen expression have been perfor...

The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherica…

LeBrun(D P),Matthews(B P),Feldman(B J),Clear… Oncogene 1997-11-20

...PBX1 is created through fusion of the genes E2A and PBX1 as a result of t(1;19) in acute lymphoblastic leukemia. We eval...

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cel…

Knoepfler(P S),Kamps(M P) Oncogene 1997-07-16

...Pbx1. Using recombinant proteins, both Pbx1 and E2a-Pbx1 heterodimerize with Hox proteins on bipartite elements, Pbx1 bi...

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