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Resistance to endotoxic shock and reduced neutrophil migration in mice deficien…

Lowell(C A),Berton(G) Proc Natl Acad Sci U S A 1998-08-06

...hck) (Hck) and p58(c-fgr) (Fgr), members of the Src-family of protein tyrosine kinases, have been shown to be defective ...

Downstream targets of urokinase-type plasminogen-activator-mediated signal tran…

Konakova(M),Hucho(F),Schleuning(W D) Eur J Biochem 1998-07-17

...hck and lck, which belong to a family of structurally and functionally related effectors participating in signalling fro...

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 …

Meng(F),Lowell(C A) EMBO J 1998-09-22

...hck-/-fgr-/-lyn-/- triple mutant cells, which are defective in spreading on fibronectin-coated surfaces in vitro and sho...

The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating…

Ward(A C),Monkhouse(J L),Csar(X F),Touw(I P)… Biochem Biophys Res Commun 1998-11-23

...Hck by the G-CSF-R in intact cells as well as in vitro. These studies revealed recruitment of Hck to activated G-CSF-R, ...

Lck associates with and is activated by Kit in a small cell lung cancer cell li…

Krystal(G W),DeBerry(C S),Linnekin(D),Litz(J) Cancer Res 1998-11-06

...Hck, and Yes were also expressed in the H526 cell line; only Yes showed a consistent increase in specific activity, whic...

The transcription factor Sp1 regulates the myeloid-specific expression of the h…

Hauses(M),Tönjes(R R),Grez(M) J Biol Chem 1998-12-23

...HCK gene expression, the genomic region containing the HCK promoter was isolated and functionally characterized. A DNA f...

Intramolecular regulatory interactions in the Src family kinase Hck probed by m…

LaFevre-Bernt(M),Sicheri(F),Pico(A),Porter(M… J Biol Chem 1998-12-23

...Hck and W260A Hck. The W260A mutant has a higher specific activity than wild type Hck. The W260A mutant requires autopho...

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK…

Manninen(A),Hiipakka(M),Vihinen(M),Lu(W),May… Virology 1998-12-17

...Hck-SH3 interaction, as measured by surface-plasmon resonance, also abolished coprecipitation of NAK. As PAK family prot...

Fusion of azurophil granules with phagosomes and activation of the tyrosine kin…

N'Diaye(E N),Darzacq(X),Astarie-Dequeker(C),… J Immunol 1998-11-18

...Hck was activated and translocated to the phagosomal membrane, whereas in neutrophils engulfing mycobacteria, Hck did no...

Common in vitro substrate specificity and differential Src homology 2 domain ac…

Sicilia(R J),Hibbs(M L),Bello(P A),Bjorge(J … J Biol Chem 1998-08-06

...Hck molecules in the purified Hck preparation were not tyrosine-phosphorylated. In contrast to intact Hck, a recombinant...

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