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A gene optimization strategy that enhances production of fully functional P-gly…

Bai(Jiangping),Swartz(Douglas J),Protasevich… PLoS One 2011-12-14

...Pgp, likely due to higher purity of Opti-Pgp preparations. Analysis of purified wild-type and Opti-Pgp by CD, DSC and li...

3'-O, 4'-O-aromatic acyl substituted 7,8-pyranocoumarins: a new class of P-glyc…

Shen(Xiaoling),Chen(Guangying),Zhu(Guoyuan),… J Pharm Pharmacol 2012-04-16

...Pgp-MDR through directly binding to substrate binding site(s) or allosteric site(s) on Pgp therefore impairing Pgp-media...

P-glycoprotein expression in high grade central osteosarcoma and normal bone ce…

Pösl(M),Amling(M),Grahl(K),Hentz(M),Ritzel(H… Gen Diagn Pathol 1997-06-00

...Pgp and chemotherapy as well as the role of Pgp in tumorigenesis of osteosarcoma, we analyzed Pgp-expression in hcg-OS. ...

Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibit…

Mairinger(Severin),Wanek(Thomas),Kuntner(Cla… Nucl Med Biol 2013-03-28

...Pgp expression levels presumably due to insufficiently high Pgp binding affinity of MC113 in relation to Pgp densities i...

Effects of hypotonic and hypoionic media on drug pumping by P-glycoprotein expr…

Ambasch(K),Cabantchik(ZI),Slotki(IN) J Cell Physiol 1995-07-00

...Pgp-) induced to express Pgp and MDR phenotype (HT-29/Pgp+) and NIH3T3 (3T3/Pgp-) cells which were stably transfected wi...

Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the hu…

Zeng(H),Lin(ZP),Sartorelli(AC) Biochem Pharmacol 2004-09-01

...Pgp in 6-MP resistance even though it is generally believed that Pgp does not transport such agents. The resistance patt...

Case-control study of multidrug resistance phenotype and response to induction …

Malagola(M),Damiani(D),Martinelli(G),Michelu… Br J Haematol 2007-01-00

...Pgp-negative (neg(ve)) ones (MFI < 6) (P = 0.16). Conversely, in the controls, the CR rate was 44% among the MDR-Pgp-pos...

Factors influencing development of portal hypertensive gastropathy in patients …

Sarin(SK),Sreenivas(DV),Lahoti(D),Saraya(A) Gastroenterology 1992-03-00

...PGP. After sclerotherapy, 21 additional patients (20.3%) developed PGP during a follow-up of 23.2 +/- 3.4 months (range,...

Functional analysis of a tryptophan-less P-glycoprotein: a tool for tryptophan …

Kwan(T),Loughrey(H),Brault(M),Gruenheid(S),U… Mol Pharmacol 2000-07-00

...Pgp at high resolution. We have used site-directed mutagenesis to modify the wild-type (WT) mouse mdr3 Pgp for tryptopha...

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug…

Seebacher(Nicole A),Lane(Darius J R),Jansson… J Biol Chem 2016-07-01

Pgp is functional on the plasma membrane and lysosomal membrane. Lysosomal-Pgp can pump substrates into the organelle, t...

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