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Inactivating CUX1 mutations promote tumorigenesis.

Wong(Chi C),Martincorena(Inigo),Rust(Alist... Nat Genet 2014-03-04

...CUX1 (cut-like homeobox 1) in ~1-5% of various tumors. Meta-analysis of CUX1 mutational status in 2,519 cases of myeloid...

Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast...

Vadnais(Charles),Shooshtarizadeh(Peiman),R... Biol Open 2014-10-16

...CUX1 transgenic mice represent a model for autocrine activation of the Wnt/β-catenin pathway. By comparing expression pr...

Clinical significance of genetic aberrations in secondary acute myeloid leuke...

Milosevic(Jelena D),Puda(Ana),Malcovati(Lu... Am J Hematol 2013-01-03

...CUX1 locus) were significantly associated with sAML, while NPM1 and FLT3 mutations associated with dnAML. Patients with ...

Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in ...

Schoenmakers(Eric F P M),Bunt(Jens),Hermer... Genes Chromosomes Cancer 2013-07-23

...CUX1) gene on chromosomal band 7q22.1 in a way which is functionally equivalent to the more frequently observed del(7q) ...

Loss of functional Dicer in mouse radial glia cell-autonomously prolongs cort...

Nowakowski(Tomasz Jan),Mysiak(Karolina San... Dev Biol 2013-12-10

...Cux1-positive neurons, many of which populated the superficial cortical layers. Injections of the S-phase marker bromode...

Delineation of a de novo 7q21.3q31.1 Deletion by CGH-SNP Arrays in a Girl wit...

Martínez-Jacobo(L),Córdova-Fletes(C),Ortiz... Mol Syndromol 2013-10-29

...CUX1 gene and potential regulatory elements downstream from DLX5 are unrelated to ectrodactyly.

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently ...

McNerney(Megan E),Brown(Christopher D),Wan... Blood 2013-04-05

...CUX1, a gene encoding a homeodomain-containing transcription factor. In 1 case, CUX1 was disrupted by a translocation, r...

A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 Afri...

Peters(Ulrike),North(Kari E),Sethupathy(Pr... PLoS Genet 2013-05-30

...CUX1, which has recently been implicated in the regulation of FTO. We did not find strong evidence for a second independ...

WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer.

Griesmann(Heidi),Ripka(Stefanie),Pralle(Mo... Neoplasia 2013-11-13

...CUX1 and demonstrated high expression levels in pancreatic cancer. However, the impact of WNT5A on drug resistance and t...

Recent topics on α-fetoprotein.

Nakao(Kazuhiko),Ichikawa(Tatsuki) Hepatol Res 2013-08-20

...CUX1, which promotes cell-cycle progression, suggesting that AFP reactivation is closely linked to hepatocyte proliferat...

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