Mutations in the KIT and PDGFRA proto-oncogenes are key drivers in gastrointestinal stromal tumors (GIST) and guide targ...
...PDGFRA amplification. Longitudinal analysis highlighted two major malignant cell-state transition patterns. First, reduc...
...PDGFRA gene, a key regulator for angiogenesis, was significantly enriched. Overexpression of miR-196a-5p significantly d...
...PDGFRA. High performance was observed for subtypes, including KIT exon 11 del-inss 557-558 (0.67) and PDGFRA exon 18 D84...
...PDGFRA, and TERT. At 16-month follow-up, two metastatic pulmonary nodules developed, one responsive to chemotherapy. The...
...PDGFRA have improved patient outcomes, yet off-target toxicities and drug resistance mutations remain major clinical cha...
...PDGFRA, FGFR1, GLI1, CDK4, ERBB3, and KIT. Pathogenic variants affecting genes involved in tumor suppression and chromat...
...PDGFRA. Although these alterations define the core molecular biology of GISTs and guide targeted therapy, they do not fu...
...PDGFRA, HAS2, and SLC5A11, have been implicated in renal involvement, while APOL1 G1/G2 risk variants are associated wit...
...PDGFRA, which enables tumor cells to proliferate in a ligand-independent manner. The critical relevance of these oncogen...
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