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The 20S proteasome as an assembly platform for the 19S regulatory complex.

Hendil(Klavs B),Kriegenburg(Franziska),Tan... J Mol Biol 2009-11-12

...Rpn2, Rpn10, Rpn11, Rpn13, and Txnl1, attached to preexisting 20S proteasomes. This early assembly complex does not yet ...

S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal ...

Zmijewski(Jaroslaw W),Banerjee(Sami),Abrah... J Biol Chem 2009-09-14

...Rpn2 in control or oxidized 26 S proteasomal complexes. These findings identify S-glutathionylation of Rpn2 as a contrib...

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by m...

Kaneko(Takeumi),Hamazaki(Jun),Iemura(Shun-... Cell 2009-06-22

...Rpn2, where p28, S5b, and p27 regulate the associations between the modules. These chaperones dissociate before completi...

The C-terminal extension of the beta7 subunit and activator complexes stabili...

Marques(António J),Glanemann(Christoph),Ra... J Biol Chem 2008-02-04

...rpn2) affecting the Rpn2 subunit inhibits attachment of the 19 S activator to the 20 S particle or its precursors. Altho...

Reduced TGF-beta1 expression and its target genes in human insulinomas.

Nabokikh(A),Ilhan(A),Bilban(M),Gartner(W),... Exp Clin Endocrinol Diabete... 2008-01-17

...RPN2) in insulinomas. Similarly, TGF-beta1 immunofluorescence analysis revealed reduced expression in insulinomas when c...

The central unit within the 19S regulatory particle of the proteasome.

Rosenzweig(Rina),Osmulski(Pawel A),Gaczyns... Nat Struct Mol Biol 2008-07-08

...Rpn2. These toroids physically link the site of substrate recruitment with the site of proteolysis. Rpn2 interfaces with...

RPN2 gene confers docetaxel resistance in breast cancer.

Honma(Kimi),Iwao-Koizumi(Kyoko),Takeshita(... Nat Med 2008-10-27

...RPN2 markedly reduced tumor growth in two types of models for drug resistance. Thus, RPN2 silencing makes cancer cells h...

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domai...

Schreiner(Patrick),Chen(Xiang),Husnjak(Kor... Nature 2008-07-07

...Rpn2/S1 simultaneously. Finally, we provide a model structure of Rpn13 complexed to diubiquitin, which provides insights...

Mass spectrometric characterization of the affinity-purified human 26S protea...

Wang(Xiaorong),Chen(Chi-Fen),Baker(Peter R... Biochemistry 2007-05-16

...Rpn2, which results in identification of two different N-termini of the protein. This work presents the first comprehens...

Immediate early gene-X1 interferes with 26 S proteasome activity by attenuati...

Arlt(Alexander),Minkenberg(Jörg),Kruse(Mar... Biochem J 2007-03-05

...Rpn2, whereas the expression of other proteasomal proteins was less or not affected. In contrast with direct apoptotic s...

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