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Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spon...

Cambier(Linda),Plate(Markus),Sucov(Henry M... Development 2014-09-16

...Rspo3 is markedly downregulated in Nkx2-5 mutants and that Rspo3 expression is regulated by Nkx2-5. Conditional inactiva...

LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in th...

Li(Ji-Yao),Chai(Biaoxin),Zhang(Weizhen),Fr... Endocrinology 2014-03-20

...Rspo3 mRNA is up-regulated by insulin. These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circu...

A conditional allele of Rspo3 reveals redundant function of R-spondins during...

Neufeld(Stanley),Rosin(Jessica M),Ambasta(... Genesis 2013-03-20

...Rspo3 during limb development and found that limbs ultimately developed normally in the absence of Rspo3 function. Howev...

Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signalin...

Moad(Heather E),Pioszak(Augen A) Biochemistry 2013-12-23

...RSPO3 > RSPO1. RSPO-receptor interactions were further characterized with a native gel electrophoretic mobility shift as...

Genome-wide association analysis of blood-pressure traits in African-ancestry...

Franceschini(Nora),Fox(Ervin),Zhang(Zhaogo... Am J Hum Genet 2013-11-05

...RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0 × 10(-8)) for either systolic or diastolic BP in a t...

Replication study of 15 recently published Loci for body fat distribution in ...

Hotta(Kikuko),Kitamoto(Aya),Kitamoto(Takuy... J Atheroscler Thromb 2013-10-17

...RSPO3 rs9491696, NFE2L3 rs1055144, ITPR2 rs718314, HOXC13 rs1443512, ZNRF3 rs4823006 and THNSL2 rs1659258.,The G-allele ...

TCDD inhibition of canonical Wnt signaling disrupts prostatic bud formation i...

Branam(Amanda M),Davis(Nicole M),Moore(Rob... Toxicol Sci 2013-10-17

...Rspo3) that promote canonical Wnt signaling is reduced; (2) expression of Lef1, Tcf1, and Wif1, established canonical Wn...

Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebr...

Matsuda(Miho),Nogare(Damian Dalle),Somers(... Development 2013-07-16

...rspo3 knockdown reduces proliferation in a manner similar to that seen in lef1 morphants. However, it does not cause clo...

Atlas of Wnt and R-spondin gene expression in the developing male mouse lower...

Mehta(Vatsal),Abler(Lisa L),Keil(Kimberly ... Dev Dyn 2012-03-16

...Rspo3 mRNAs. These results reveal sexual differences in WNT/β-catenin signaling in fetal LUT, supporting the idea that t...

Clinical review: Genome-wide association studies of skeletal phenotypes: what...

Hsu(Yi-Hsiang),Kiel(Douglas P) J Clin Endocrinol Metab 2012-12-18

...RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, P...

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