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State-of-the-art of small molecule inhibitors of the TAM family: the point of...

Baladi(Tom),Abet(Valentina),Piguel(Sandrin... Eur J Med Chem 2016-08-25

...Tyro3, Axl and Mer) is implicated in cancer development, autoimmune reactions and viral infection and is therefore emerg...

The roles of TAM receptor tyrosine kinases in the mammalian testis and immuno...

Deng(Tingting),Chen(Qiaoyuan),Han(Daishu) Front Biosci (Landmark Ed) 2016-10-19

...Tyro3, Axl, and Mer, are collectively called as TAM receptors. TAM receptors have two common ligands, namely, growth arr...

Exposure to TiO2 Nanoparticles Induces Immunological Dysfunction in Mouse Tes...

Hong(Fashui),Wang(Yajing),Zhou(Yingjun),Zh... J Agric Food Chem 2016-08-11

...Tyro3 (-18.16 to -66.6%), Axl (-14.7 to -57.99%), Mer (-7.98 to -72.62%), and IκB (-11.25 to -63.16%), suppression of cy...

The TAM receptor Mertk protects against neuroinvasive viral infection by main...

Miner(Jonathan J),Daniels(Brian P),Shresth... Nat Med 2016-05-13

The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following ...

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Micr...

Happonen(Kaisa E),Tran(Sinh),Mörgelin(Matt... J Biol Chem 2016-11-10

...Tyro3, Axl, and Mer (TAMs) and their ligands protein S and Gas6 are involved in the uptake of phosphatidylserine-exposin...

The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type...

Chan(Pamela Y),Carrera Silva(Eugenio A),De... Science 2016-04-11

...Tyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit ...

Emerging role of CD300 receptors in regulating myeloid cell efferocytosis.

Voss(Oliver H),Tian(Linjie),Murakami(Yousu... Mol Cell Oncol 2016-06-16

...Tyro3, Axl, and MerTK receptor tyrosine kinases (TAMs), T-cell immunoglobulin and mucin domain containing 1 and 4 (TIM1/...

Inhibition of TYRO3/Akt signaling participates in hypoxic injury in hippocamp...

Zhu(Yan-Zhen),Wang(Wei),Xian(Na),Wu(Bing) Neural Regen Res 2016-06-23

In this study, we investigated the role of the TYRO3/Akt signaling pathway in hypoxic injury to hippocampal neurons. 3-(...

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme.

Knubel(Kristina H),Pernu(Ben M),Sufit(Alex... Oncotarget 2015-01-27

...Tyro3, Axl, and MerTK. Axl and MerTK exhibit little to no expression in normal brain but are highly expressed in gliobla...

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients...

Recarte-Pelz(Pedro),Tàssies(Dolors),Espino... Arthritis Res Ther 2015-06-03

...Tyro3, Axl and MerTK receptor tyrosine kinase (TAM) family, involved in apoptotic cell clearance (efferocytosis) and reg...

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