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TP53 BRCA1 CRISPR single-cell cancer

Srivastava(Shalini),Mishra(Satyendra),Suro... Biosci Rep 0000-00-00

...Mdm2) (S166), in MCF-7 cells. C1 appeared to induce p53 mediated apoptosis in MCF-7 cells. Interestingly, C1 showed more...

Valente(Liz J),Aubrey(Brandon J),Herold(Ma... Cell Rep 0000-00-00

Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabil...

Vivenza(Daniela),Monteverde(Martino),Latta... Int J Biol Markers 0000-00-00

...MDM2 gene.,In wild-type TP53 cases, overall survival (OS) was longer in 72RR and less favorable in 72PP (p = 0.005); whe...

Mariano(Fernanda Viviane),Giovanetti(Karin... Braz J Otorhinolaryngol 0000-00-00

...MDM2, WIF1, WHSC1L1, LIRG3, CDK4 in CXAP from RPA can be a significant promotional factor in malignant transformation.

Tramutola(Antonella),Pupo(Gilda),Di Domeni... J Alzheimers Dis 0000-00-00

...MDM2/p53 complex level and lower levels of SIRT1. Activation of p53 was associated with a number of targets (BAX, PARP1,...

Jin(H),Lee(K),Kim(Y-H),Oh(H K),Maeng(Y-I),... Oncogene 0000-00-00

...MDM2, allowing for efficient MDM2-mediated IER3 degradation by facilitating an association between MDM2 and IER3. Moreov...

Mungamuri(Sathish Kumar),Qiao(Rui F),Yao(S... Cell Rep 0000-00-00

...MDM2-mediated SUV39H1 degradation. Here, we present evidence that the USP7 deubiquitinase protects SUV39H1 from MDM2-med...

Park(Ji Eun),Park(Byoungduck),Chae(In Gyeo... Oncol Rep 0000-00-00

...Mdm2). Furthermore, CA generated reactive oxygen species (ROS), and pretreatment with ROS scavenger N-acetyl cysteine (N...

Warner(Kristy A),Nör(Felipe),Acasigua(Gers... Clin Cancer Res 0000-00-00

...MDM2-p53 interaction (MI-773) in preclinical models of ACC.,To evaluate the anti-tumor effect of MI-773, we administered...

Frum(Rebecca A),Love(Ian M),Damle(Priyadar... Mol Cancer Res 0000-00-00

...MDM2-dependent polyubiquitination of otherwise monoubiquitinated mutant p53. Caffeine treatment rescued MDM2-dependent p...

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