...MDM2 and MDM4, to indirectly regulate the activity and function of p53. On the other hand, p53 also regulates the transc...
...MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted...
...MDM2 (n = 5). Fifteen KRAS/EGFR/BRAFwt tumors had MET mutations/amplifications. In CRC, amplified IGF2 was most prevalen...
...Mdm2) protein, its translocation to the nucleus and degradation of the tumor suppressor p53. We show that Mif, the Macro...
...MDM2 genomic locus together with a homologous repair template for creating the mutation of MDM2 T309G in human primary r...
...MDM2), rs2299939 (PTEN) and rs8178085, rs12334811 (DNA-PKcs) affected the sensitivity to chemotherapy, so did the rs8178...
...MDM2, without affecting Noxa gene. The results presented in this work support the notion that the transcription factors ...
...MDM2 and p53 as the model combination of E3 and its target protein. The AlphaScreen assay specifically detected the bind...
...MDM2-mediated ubiquitin-dependent proteolysis and by directly binding to its central DNA binding domain and preventing i...
...MDM2 was identified as a direct target of miR-5003-3p, the downregulation of which induced Snail stabilization. E-cadher...
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