...MDM2/MDMX complexes with p53 has been pivotal for the identification of several classes of inhibitors of the p53-MDM2/MD...
...MDM2 inhibitors, and X-ray structures of MDM2 complexed with several ligands are available in the Brookhaven Protein Dat...
...Mdm2 and Mdmx, induce genome instability will be described.
...MDM2 gene amplification, all in keeping with WDL. We highlight hibernoma-like morphology as part of the histologic spect...
...MDM2's hydrophobic pocket activate p53. However, these agents act allosterically and have agonist effects on MDM2's prot...
...MDM2 amplification, were not identified. Copy number analysis revealed intratumoral heterogeneity and evidence for diver...
...MDM2, CPM, YEATS4, DDIT3, GLI1 (five each), HMGA2 and STAT6 (four), without association with sarcomatous overgrowth stat...
...MDM2 target genes at the whole-genome level highlights an important role for ATF3/4 transcription factors in tethering M...
...MDM2-null islets can be rescued by restoring PC expression. Under diabetogenic conditions, MDM2 and p53 are upregulated,...
...MDM2, STAG1, E2F4, FGF4, FGF19, RHOBTB2, UBE2QL1, DCN and HSP90AA1) were enriched and interconnected in five pathways in...
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