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Redox maintenance and concerted modulation of gene expression and signaling p...

Soltani(Behrooz),Ghaemi(Nasser),Sadeghizad... Chem Biol Interact 0000-00-00

...MDM2, IFNG, and BBC3 (PUMA) genes after DNC treatment.

Coinhibition of overexpressed genes in acute myeloid leukemia subtype M2 by g...

Zaimy(M A),Jebali(A),Bazrafshan(B),Mehrtas... Cancer Gene Ther 0000-00-00

...MDM2, Bcl-2, BIRC5 (survivin) and XIAP, in acute myeloid leukemia subtype 2 (AML-M2). The smart nanostructures were func...

Genome-scale functional analysis of the human genes modulating p53 activity b...

Kim(Dong Min),Choi(Seung-Hyun),Yeom(Young ... Biochem Biophys Res Commun 0000-00-00

...MDM2 expression occurs due to alterations in MDM2 upstream regulators. In this study, a high MDM2 transcription level wa...

Pioglitazone inhibits EGFR/MDM2 signaling-mediated PPARγ degradation.

Shi(Juanjuan),Zhang(Wenbo),You(Mengli),Xu(... Eur J Pharmacol 0000-00-00

...MDM2 signaling induces PPARγ phosphorylation and degradation. Here we found that cancer cells in response to EGF reduced...

MDM2-MDM4 molecular interaction investigated by atomic force spectroscopy and...

Moscetti(Ilaria),Teveroni(Emanuela),Morett... Int J Nanomedicine 0000-00-00

...MDM2-MDM4 heterodimer, similar to related complexes involved in the p53 network. Furthermore, the MDM2-MDM4 complex is c...

Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal...

Liu(S),Tackmann(N R),Yang(J),Zhang(Y) Oncogene 0000-00-00

...Mdm2 but not Apc;Mdm2 colon tumors. These data establish that the RP-MDM2-p53 pathway, in contrast to the p19ARF-MDM2-p5...

FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by ...

Liu(T),Xiong(J),Yi(S),Zhang(H),Zhou(S),Gu(... Oncogene 0000-00-00

...MDM2 and induces MDM2 degradation. We demonstrate that FKBP12 degrades MDM2 through binding to MDM2 protein, disrupting ...

Transcript Analysis for Internal Biodosimetry Using Peripheral Blood from Neu...

Edmondson(David A),Karski(Erin E),Kohlgrub... Radiat Res 0000-00-00

...MDM2. Six genes were significantly modulated upon exposure to (131)I-mIBG at 72 h, as well as at 96 h. Four genes varied...

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive functio...

Tzaridis(Theophilos),Milde(Till),Pajtler(K... Oncotarget 0000-00-00

...MDM2 inhibition in ependymoma, we evaluated the effects of Actinomycin-D and Nutlin-3 treatment in two preclinical epend...

Gene expression profiling analysis of the role of miR-22 in clear cell ovaria...

Zhen(Y B),Guo(X L),Xu(B),Zhao(H W),Xu(C J) Neoplasma 0000-00-00

...MDM2 oncogene, E3 ubiquitin protein ligase (MDM2), and thrombospondin 1 (THBS1) were involved in the p53 signaling pathw...

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