...Mdm2-mediated proteasomal degradation of p53, throughout the ribosomal protein-Mdm2-p53 pathway. P53 stabilization hinde...
...MDM2 and MDM4, no one has yet reached clinical application. In the past, several efforts have been employed to develop m...
...MDM2 T309G polymorphism and endometrial cancer risk. There was a significant association between MDM2 T309G polymorphism...
...Mdm2) degradation. Thus, VHL may involved in the PDCD5 mediated apoptosis and autophagy after MCAO. In the present study...
...MDM2), promoting the activation of p53 signaling and MC-LR-mediated cell apoptosis. Moreover, cells responded to MC-LR w...
...MDM2 circuitry. Our strategy using the graphical model to reconstruct gene interaction work with biologically-inspired c...
The p53-MDM2 interaction is an anticancer drug target under investigation in the clinic. Our compound NVP-CGM097 is one ...
...MDM2, which not only inhibited MDM2-p53 interaction but also promoted MDM2 degradation. CPI-7c bound to both RING and N-...
...MDM2-P53 feedback loop. Additionally, H. pylori triggers the alteration of other p53 isoforms. Dysregulation of p53 by H...
...MDM2 protein, cyclin D1, Ki-67, Bcl-2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c-met, DNA meth...
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