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Structural studies and SH3 domain binding properties of a human antiviral saliv…

Righino(Benedetta),Pirolli(Davide),Radicioni… Biopolymers 0000-00-00

...Hck, and c-Src SH3 domains gave positive results in terms of interaction, showing dissociation constants ranging from na...

An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.

Lopez(Sophie),Voisset(Edwige),Tisserand(Juli… Oncotarget 0000-00-00

...HCK. Accordingly, FLT3-ITD failed to transform primary hematopoietic progenitor cells from Cdk6-/- mice. Our results dem...

Novel virtual lead identification in the discovery of hematopoietic cell kinase…

Bavi(Rohit),Kumar(Raj),Rampogu(Shailima),Kim… J Recept Signal Transduct Res 0000-00-00

...Hck) is associated with drug resistance in chronic myeloid leukemia. Additionally, Hck activity has also been connected ...

LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosph…

Kelher(Marguerite R),McLaughlin(Nathan J D),… J Leukoc Biol 0000-00-00

...Hck. We hypothesize that lysoPCs induce Hck-dependent activation of protein kinase C (PKC), resulting in phosphorylation...

Influence of Immunology Knowledge on Healthcare and Healthy Lifestyle.

Abu Kassim(Noor Lide),Saleh Huddin(Afiqah Bi… PLoS One 0000-00-00

...HCK and the other variables. However, significant positive correlation was observed between primary HCK and controlled u...

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinas…

Wei(Chengguo),Li(Li),Menon(Madhav C),Zhang(W… J Am Soc Nephrol 0000-00-00

...Hck with high selectivity. In vitro, Hck overexpression activated the TGF-β/Smad3 pathway, whereas HCK knockdown inhibit...

Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplasti…

Roversi(Fernanda Marconi),Pericole(Fernando … Biochim Biophys Acta 0000-00-00

...HCK) inhibitor (iHCK-37) that was able to reduce PI3K/AKT and MAPK/ERK pathways activation after erythropoietin inductio...

Auto-thiophosphorylation activity of Src tyrosine kinase.

Cabail(M Zulema),Chen(Emily I),Koller(Antoni… BMC Biochem 0000-00-00

...Hck, and IGF1 receptor) also auto-thiophosphorylate in the presence of Ni(2+). Tyr416-thiophosphorylated Src is resistan...

The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagoc…

Wetzel(Dawn M),Rhodes(Emma L),Li(Shaoguang),… J Cell Sci 0000-00-00

...Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is require...

Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for t…

Nakayama(Hitoshi),Kurihara(Hidetake),Morita(… Sci Signal 0000-00-00

...Hck from the phagosomes of neutrophils that internalized nonpathogenic mycobacteria but not from those that internalized...

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