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Novel insights into genetic associations and drug targets of mitochondria-ass...

Sun(W),Pan(X),Yang(H),Wang(X),Zhang(X),Pan... J Affect Disord 2026-01-01

...BCHE, and KNG1 emerged as potential therapeutic targets. Our findings revealed a causal link between mitochondria-associ...

Comparative Profiling and In Silico Multitarget Analysis of Volatile Constitu...

Stoyanov(S),Dincheva(I),Kolev(I),Şenol(H),... Plants (Basel) 2026-06-08

...BChE), for which inhibitory activity of plant-derived compounds has previously been reported. Steam distillation, gas ch...

Investigating Phenolic Contents, Antioxidant Capacity and Enzyme Inhibition A...

Oyman Şahinkaya(BU),Ünsal Gürer(Ç),Kurt Ce... Chem Biodivers 2026-06-00

...BChE), and urease (98.67%) inhibition, and all vinegars showed superior elastase and tyrosinase inhibition. Results high...

Microwave-assisted green synthesis and biological evaluation of a novel isati...

Lotfy(EM),Seliem(IA) Bioorg Chem 2026-09-15

...BChE) using Ellman's method, displaying micromolar AChE inhibition with noticeable selectivity over BChE. Kinetic analys...

Rational design, synthesis, and biological evaluation of chalcone hybrids inc...

Lin(Z),Hu(L),Liu(Y),Ning(W),Wang(S),Fu(ZY)... Bioorg Med Chem Lett 2026-11-00

...BChE). Among them, compound 2e displayed the most inhibitory activity against AChE, BChE and β-amyloid (Aβ42) with IC50 ...

Multidimensional pharmacological evaluation of Umbilicus horizontalis (Guss.)...

Dibi(AR),Aouachria(S),Benammar(L),Bensouic... J Ethnopharmacol 2026-11-15

...BChE) inhibition assays. Stem crude extract (SCrE) showed the highest phenolic (209.37 ± 7.98 μg GAE/mg) and flavonoid (...

Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neu...

Rullo(M),La Spada(G),Brazzolotto(X),Marche... Eur J Med Chem 2026-10-15

...BChE) and monoamine oxidase B (MAO B). Both enzymes emerged as promising targets for tuning the inflammatory response wi...

Design, synthesis, and biological evaluation of novel multifunctional caffeic...

Kumar(S),Kumar(N),Krishnamurthy(S),Modi(G) Bioorg Med Chem 2026-09-00

...BChE cholinesterase inhibition while maintaining or enhancing the multifunctional activity of the previously identified ...

Integrated multi-omics and experimental validation reveal CSK and FBLN1 as ke...

Li(R),Zhang(R),Liu(J),Tang(Y) Vascul Pharmacol 2026-06-06

...BCHE-With stable binding to stanozolol. Functional assays showed CSK upregulation in macrophages and FBLN1 downregulatio...

A comprehensive exploration of the structure-activity relationships, multitar...

Malvankar(A),Raut(M),Singh(SK),Singh(R),Ma... Future Med Chem 2026-07-00

...BChE), amyloid beta (Aβ) accumulation, tau aggregation, neuroinflammation and oxidative stress. Recent reviews label 1,2...

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