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DISCopathies: brain disorders related to DISC1 dysfunction.

Korth(Carsten) Rev Neurosci 2010-05-06

...NDEL1, NDE1, LIS1, as well as the signaling molecules, GSK-3beta, PDE4B, and others. DISC1 oligomerizes, can form misass...

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase...

Collins(Daniel M),Murdoch(Hannah),Dunlop(A... Cell Signal 2009-02-06

...Ndel1. BRET assessed Ndel1-Ndel1 self-interaction is amplified through the binding of PDE4 isoforms. For PDE4D3 this eff...

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis...

Sawamura(N),Ando(T),Maruyama(Y),Fujimuro(M... Mol Psychiatry 2009-04-08

...NDEL1) and activating transcription factor 4 (ATF4)/CREB2. Nevertheless, a role for DISC1 in vivo remains to be elucidat...

Expression profiles of ndel1a and ndel1b, two orthologs of the NudE-Like gene...

Drerup(Catherine M),Ahlgren(Sara C),Morris... Gene Expr Patterns 2009-11-03

...NDEL1 orthologs in the zebrafish, ndel1a and ndel1b. ndel1a is expressed predominantly in the anterior central nervous s...

Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors...

Tomppo(Liisa),Hennah(William),Lahermo(Päiv... Biol Psychiatry 2009-08-20

...NDEL1 (rs17806986, p = .0038). Greater significance was observed with allelic haplotypes of PDE4D (p = .00084), PDE4B (p...

Aurora A moonlights in neurite extension.

Lefkowitz(Gloria Kuo),Gleeson(Joseph G) Nat Cell Biol 2009-09-22

...NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell ...

An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by...

Mori(Daisuke),Yamada(Masami),Mimori-Kiyosu... Nat Cell Biol 2009-09-22

...NDEL1 at S251 and recruitment. Suppression of aPKC, Aurora A or TPX2, or disruption of Ndel1, results in severe impairme...

Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by s...

Leliveld(S Rutger),Hendriks(Philipp),Miche... Biochemistry 2009-09-21

...NDEL1) binding site at residues 802-839. Here, we performed mutagenesis studies of the C-terminal domain of the DISC1 pr...

NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction.

Bradshaw(Nicholas J),Christie(Sheila),Soar... Neurosci Lett 2009-04-27

...NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little know...

Opposing effects of Ndel1 and alpha1 or alpha2 on cytoplasmic dynein through ...

Ding(Chong),Liang(Xujun),Ma(Li),Yuan(Xiaob... J Cell Sci 2009-10-19

...Ndel1, a Lis1- and dynein-binding protein that is also crucial for dynein function, restored Golgi and endosome distribu...

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