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The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome.

Isono(Erika),Nishihara(Kiyoshi),Saeki(Yasu... Mol Biol Cell 2007-05-02

...rpn2, of the yeast Saccharomyces cerevisiae. We found that, although lid formation was abolished in rpn5-1 mutant cells ...

A novel proteasome interacting protein recruits the deubiquitinating enzyme U...

Hamazaki(Jun),Iemura(Shun-Ichiro),Natsume(... EMBO J 2006-11-13

...Rpn2 via its amino-terminus. The majority of 26S proteasomes contain hRpn13, but a portion of them does not, indicating ...

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by...

Yao(Tingting),Song(Ling),Xu(Wei),DeMartino... Nat Cell Biol 2006-10-18

...Rpn2) subunit of the 19S complex. Adrm1 (human Rpn13, hRpn13) binds the carboxy-terminal tail of Uch37, a region that is...

Proteasome dysfunction in aged human alpha-synuclein transgenic mice.

Chen(Li),Thiruchelvam(Mona J),Madura(Kiran... Neurobiol Dis 2006-09-06

...Rpn2, and the level of soluble total high MW ubiquitin cross-reacting proteins. Line hw alpha-SYN-5 had significant, but...

The bipartite nuclear localization sequence of Rpn2 is required for nuclear i...

Wendler(Petra),Lehmann(Andrea),Janek(Katha... J Biol Chem 2004-12-10

...Rpn2 and Rpt2, a non-ATPase subunit and an ATPase subunit of the base complex, harbor functional NLSs. The Rpt2 NLS dele...

Caspase activation inhibits proteasome function during apoptosis.

Sun(Xiao-Ming),Butterworth(Michael),MacFar... Mol Cell 2004-05-24

...Rpn2), which with S5a and S2 (Rpn1) holds together the lid and base of the 19S regulatory complex. This caspase-mediated...

What curves alpha-solenoids? Evidence for an alpha-helical toroid structure o...

Kajava(Andrey V) J Biol Chem 2003-02-12

...Rpn2/S1 proteins, which represent the largest subunits of the 26 S proteasome, has been proposed. The model has a novel ...

N-Terminal modifications of the 19S regulatory particle subunits of the yeast...

Kimura(Yayoi),Saeki(Yasushi),Yokosawa(Hide... Arch Biochem Biophys 2003-02-13

...Rpn2, Rpn3, Rpn5, Rpn6, and Rpn8, were NatA substrates, and that 2 subunits, Rpt3 and Rpn11, were NatB substrates. Mass ...

Identification of ubiquitin-like protein-binding subunits of the 26S proteasome.

Saeki(Yasushi),Sone(Takayuki),Toh-e(Akio),... Biochem Biophys Res Commun 2002-10-11

...Rpn2 were identified as Ubl-binding subunits. Taken together, the results suggest that the Rpn1 and Rpn2 in the base sub...

A detailed deletion map of chromosome 20 in human oral squamous cell carcinom...

Imai(F L),Uzawa(K),Miyakawa(A),Shiiba(M),T... Int J Mol Med 2001-01-11

...RPN2 on 20q12-13.1 exhibited higher frequencies of LOH, 27.6% and 31.4%, respectively. The LOH incidence was significant...

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