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Glucokinase regulatory protein: complexity at the crossroads of triglyceride ...

Raimondo(Anne),Rees(Matthew G),Gloyn(Anna ... Curr Opin Lipidol 2015-12-01

Glucokinase regulator (GCKR) encodes glucokinase regulatory protein (GKRP), a hepatocyte-specific inhibitor of the gluco...

Preserving Mafa expression in diabetic islet β-cells improves glycemic contro...

Matsuoka(Taka-aki),Kaneto(Hideaki),Kawashi... J Biol Chem 2015-07-02

...Gckr. Importantly, the levels of human GSTA1 were also compromised in T2DM islets. Collectively, these results illustrat...

A genetic risk score is associated with hepatic triglyceride content and non-...

León-Mimila(Paola),Vega-Badillo(Joel),Guti... Exp Mol Pathol 2015-06-15

...GCKR and PPP1R3B polymorphisms were associated with higher HTG content (P < 0.05 for PNPLA3, LYPLAL1, GCKR polymorphisms...

Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype go...

Zhou(Zhao-Wei),Cui(Ling-Ling),Han(Lin),Wan... BMC Med Genet 2015-10-19

...GCKR, corrected p = 1.78E(-4), OR = 0.723), rs1183201 (located in SLC17A1, corrected p = 1.39E(-7), OR = 0.572) and rs50...

Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver ...

Kitamoto(Aya),Kitamoto(Takuya),Nakamura(Ta... Endocr J 2015-04-14

...GCKR rs780094, TRIB1 rs2954021, and PNPLA3 rs738409 for epistatic effects. The A-allele of rs780094 in GCKR (P = 0.0024)...

Common genetic variants contribute to primary hypertriglyceridemia without di...

De Castro-Orós(Isabel),Cenarro(Ana),Tejedo... Circ Cardiovasc Genet 2015-07-23

...GCKR variants were positively correlated with plasma triglycerides, whereas minor alleles of ADIPOR2, ANGPTL3, LPL, and ...

[Association between rs780094 polymorphism in GCKR and plasma lipid levels in...

Shang(Xiaorui),Song(Jieyun),Liu(Fanghong),... Zhonghua Liu Xing Bing Xue ... 2015-01-22

To investigate the association between rs780094 polymorphism in glucokinase regulatory protein (GCKR) and plasma lipid l...

Common variant in the glucokinase regulatory gene rs780094 and risk of nonalc...

Zain(Shamsul Mohd),Mohamed(Zahurin),Mohame... J Gastroenterol Hepatol 2015-09-10

Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associat...

Inheritance of rare functional GCKR variants and their contribution to trigly...

Rees(Matthew G),Raimondo(Anne),Wang(Jian),... Hum Mol Genet 2015-06-03

...GCKR, encoding glucokinase regulatory protein. Eighteen rare non-synonymous GCKR variants identified in these 791 indivi...

Genetic variability of GCKR alters lipid profiles in children with monogenic ...

Tracz(A),Madzio(J),Gnys(P),Malachowska(B),... Exp Clin Endocrinol Diabete... 2015-06-12

...GCKR TT homozygotes among GCK-MODY patients (10.9% in GCK-MODY vs. 17.7% in T1DM, p=0.0651). GCKR genotypes showed signi...

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