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Two novel human serine/threonine kinases with homologies to the cell cycle re...

Levedakou(E N),He(M),Baptist(E W),Craven(R... Oncogene 1994-07-14

...nek1 gene product, the relative of the fungal G2-M regulator, nimA. STK1 and STK2 display a variable pattern of expressi...

A Trypanosoma brucei gene family encoding protein kinases with catalytic doma...

Gale(M),Parsons(M) Mol Biochem Parasitol 1993-07-20

...Nek1, a bifunctional kinase, and NIMA, a protein serine/threonine kinase. Both alleles at the nrkB locus in T. brucei st...

A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cel...

Letwin(K),Mizzen(L),Motro(B),Ben-David(Y),... EMBO J 1992-11-02

...Nek1. Nek1 contains an N-terminal protein kinase domain which is most similar (42% identity) to the catalytic domain of ...

A NIMA-related kinase, CNK4, regulates ciliary stability and length.

Meng(Dan),Pan(Junmin) Mol Biol Cell 0000-00-00

...Nek1 and Nek8 cause cilia-related disorders. The ciliary functions of Nrks are mostly revealed by genetic studies; howev...

ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion.

Dang(Tuyen T),Westcott(Jill M),Maine(Erin ... Oncotarget 0000-00-00

...NEK1, along with Slug and Axl. Notably, lung squamous cell carcinoma migration also required ΔNp63α dependent FAT2 and S...

Frequent Nek1 overexpression in human gliomas.

Zhu(Jun),Cai(Yu),Liu(Pin),Zhao(Weiguo) Biochem Biophys Res Commun 0000-00-00

...Nek1 inhibited glioma cell (U87-MG/U251-MG) growth. Nek1 siRNA also sensitized U87-MG/U251-MG cells to temozolomide (TMZ...

Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication ...

Spies(Julian),Waizenegger(Anja),Barton(Oli... Mol Cell 0000-00-00

...Nek1) has established roles in apoptosis and cell cycle regulation. We show that human Nek1 regulates homologous recombi...

Compound heterozygous NEK1 variants in two siblings with oral-facial-digital ...

Monroe(Glen R),Kappen(Isabelle Fpm),Stokma... Eur J Hum Genet 0000-00-00

...NEK1). The novel variant c.464G>C disturbs normal splicing in an essential region of the kinase domain. The nonsense var...

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Kenna(Kevin P),van Doormaal(Perry T C),Dek... Nat Genet 0000-00-00

...NEK1 LOF variants (3,362 samples analyzed). In total, we observed NEK1 risk variants in nearly 3% of ALS cases. NEK1 has...

Amyotrophic lateral sclerosis: recent genetic highlights.

White(Matthew A),Sreedharan(Jemeen) Curr Opin Neurol 0000-00-00

...NEK1. These have mostly been identified through large exome screening studies, though traditional linkage approaches and...

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