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microRNA-140 targets RALA and regulates chondrogenic differentiation of human...

Karlsen(Tommy A),Jakobsen(Rune B),Mikkelse... Stem Cells Dev 2014-09-08

...RALA, a small GTPase, was identified as a miR-140 target and knockdown experiments showed that RALA regulated SOX9 at th...

Longest neurite-specific activation of Rap1B in hippocampal neurons contribut...

Nakamura(Takeshi),Yasuda(Sayaka),Nagai(Hir... Genes Cells 2014-08-08

...RalA and Nore1A, whereas Rap1B-G12V/Y40C activated PI3-kinase. RalA was activated in the tip of stage 3 axons, and RalA-...

The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containi...

Popovic(Milica),Jakobi(Arjen J),Rensen-de ... J Struct Biol 2014-03-20

...RalA and RalB and couples Ras- to Ral-signalling. Here the crystal structure of the catalytic module of Rlf consisting o...

R-α lipoic acid γ-cyclodextrin complex increases energy expenditure: a 4-mont...

Nikolai(Sibylle),Huebbe(Patricia),Metges(C... Nutrition 2014-09-08

...RALA-CD resulted in a significant increase in energy expenditure. However, both RALA per se (without γ-cyclodextrin) and...

Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling i...

Martin(Timothy D),Chen(Xiao-Wei),Kaplan(Re... Mol Cell 2014-04-11

...RalA/B GTPases and for RalGAPα/β, but not Tsc1/2. This prompted our investigation to determine whether RalGAPs additiona...

GEF-H1: orchestrating the interplay between cytoskeleton and vesicle traffick...

Pathak(Ritu),Dermardirossian(Celine) Small GTPases 2014-11-24

...RalA GTPase, which in turn regulates the localization and the assembly of exocyst components and exocytosis. Our work de...

Discovery of small-molecule Ras inhibitors that display antitumor activity by...

Shima(Fumi),Yoshikawa(Yoko),Matsumoto(Shig... Enzymes 2014-08-05

...RalA, and Sos, indicating the blockade of interaction with multiple effectors. Moreover, they exhibit antitumor activity...

Preferential autoimmune response in prostate cancer to cyclin B1 in a panel o...

Dai(Liping),Li(Jitian),Ortega(Rosalia),Qia... J Immunol Res 2014-12-03

...RalA, MDM2, and NPM1) in PCa reached 80.5%, significantly higher than that in normal control sera. In summary, autoantib...

The hyper-diverse ant genus Tetramorium Mayr (Hymenoptera, Formicidae) in the...

Hita Garcia(Francisco),Fisher(Brian L) Zookeys 2014-07-10

...rala sp. n., T. schaufussii Forel, 1891, T. sikorae Forel, 1892 (= T. latior (Santschi, 1926)), T. scutum sp. n., T. xan...

RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuro...

Das(Amlan),Gajendra(Sangeetha),Falenta(Kat... J Cell Sci 2014-09-19

...RalA and its effector, the exocyst, regulate the morphology and polarized migration of neural progenitors derived from t...

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