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Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine k...

Suh(Young-Ah),Jo(Se-Young),Lee(Hwa-Young),... Int J Oncol 2015-10-05

...Tyro3 receptor tyrosine kinases (RTKs) at mRNA and protein level, which account for its cytotoxic activity. We further f...

Targeted GAS6 delivery to the CNS protects axons from damage during experimen...

Gruber(Ross C),Ray(Alex K),Johndrow(Christ... J Neurosci 2015-02-19

Growth arrest-specific protein 6 (GAS6) is a soluble agonist of the TYRO3, AXL, MERTK (TAM) family of receptor tyrosine ...

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of ...

Lee(Chuhee) Mol Med Rep 2015-12-30

...Tyro3 by transfecting Tyro3-specific small interfering RNA into the SKOV3/TR cells reduced the proliferative capacity of...

Role of growth arrest-specific gene 6 in the development of fungal allergic a...

Shibata(Takehiko),Ismailoglu(Ugur Burcin),... Am J Respir Cell Mol Biol 2015-01-02

...Tyro3, Axl, and Mertk receptors, but little is known about its role in allergic airway disease. We investigated the role...

Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma.

Waizenegger(J S),Ben-Batalla(I),Weinhold(N... Leukemia 2015-05-08

...Tyro3 and Mer (TAM receptors) in myeloma is unknown. We therefore investigated their expression in myeloma cell lines an...

Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns...

Tsou(Wen-I),Nguyen(Khanh-Quynh N),Calarese... J Biol Chem 2015-02-19

TYRO3, AXL, and MER receptors (TAMs) are three homologous type I receptor-tyrosine kinases that are activated by endogen...

Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells d...

Nguyen(Khanh-Quynh N),Tsou(Wen-I),Calarese... J Biol Chem 2015-02-19

...TYRO3, AXL, and MERTK) receptor tyrosine kinases, has complex and diverse roles in cell biology. On the one hand, knock-...

Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and co...

Rothlin(Carla V),Leighton(Jonathan A),Ghos... Inflamm Bowel Dis 2015-03-30

...Tyro3, Axl, and Mertk (TAM) and their ligands Gas6 and Protein S, have emerged as potent negative regulators of innate i...

Benzylidene-indolinones are effective as multi-targeted kinase inhibitor ther...

Ho(Han Kiat),Chua(Boon Tin),Wong(Winnie),L... Mol Oncol 2015-06-23

...Tyro3 and EphA2 phosphorylation. Gene silencing of these targets ameliorated the cytotoxic potential of 47 on the HuH7 c...

Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron m...

Salian-Mehta(Smita),Xu(Mei),Pierce(Angela)... Mol Cell Endocrinol 2015-06-09

...Tyro3, Axl, Mer) receptor tyrosine kinases in GnRH neuronal development and reproductive function. It is unclear if TAM ...

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