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A low but functionally significant MDR1 expression protects primitive haemopoie…

Smeets(M),Raymakers(R),Vierwinden(G),Penning… Br J Haematol 1997-02-00

...Pgp level, functionally this Pgp appeared to be very important in protecting primitive progenitors against anthracycline...

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcin…

Herzog(CE),Tsokos(M),Bates(SE),Fojo(AT) J Biol Chem 1993-02-05

...Pgp antagonist. Corresponding changes in Pgp were demonstrated with addition and removal of the Pgp antagonists. Increas...

Common expression of the multidrug resistance marker P-glycoprotein in B-cell c…

Sparrow(RL),Hall(FJ),Siregar(H),Van der Weyd… Leuk Res 1993-11-00

...Pgp suggesting that these cells may be the potential precursors to the B-CLL cell. We conclude that Pgp expression and d...

The role of multidrug resistance and its pharmacological modulation in acute my…

List(AF) Leukemia 1996-04-00

...Pgp function have been targeted for investigation in elderly AML patients. Non-Pgp mechanisms responsible for multidrug ...

Both P-glycoprotein nucleotide-binding sites are catalytically active.

Urbatsch(IL),Sankaran(B),Bhagat(S),Senior(AE) J Biol Chem 1995-11-10

...Pgp) caused complete inhibition of Pgp ATPase activity, with reactivation rates at 37 degrees C of 1.4 x 10(-3) s-1 (t1/...

Daunorubicin pharmacokinetics and the correlation with P-glycoprotein and respo…

Galettis(P),Boutagy(J),Ma(DD) Br J Cancer 1994-08-00

...Pgp positive and 18 Pgp negative. There was no correlation between patient response and the presence of Pgp (P > 0.1), n...

Mutation of glycine 185 to valine alters the ATPase function of the human P-gly…

Rao(US) J Biol Chem 1995-03-24

...Pgp, the wild-type and the mutant Val185 Pgps were expressed in Sf9 insect cells, and their biochemical properties were ...

Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3',4'-pentame…

Choi(CH),Sun(KH),An(CS),Yoo(JC),Hahm(KS),Lee… Biochem Biophys Res Commun 2002-07-26

...Pgp, suggesting that it is not a substrate for Pgp. Flow cytometry showed that sinensetin increased drug accumulation in...

Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression--a…

Rittierodt(M),Harada(K) Exp Toxicol Pathol 2003-07-00

...PGP) coded by the multidrug resistance 1 (MDR1) gene and a subsequent release of drugs from the tumor cells. For the che...

The multidrug transporter P-glycoprotein: a mediator of melanoma invasion?

Colone(M),Calcabrini(A),Toccacieli(L),Bozzut… J Invest Dermatol 2008-04-00

...Pgp) in the invasion potential of drug-sensitive (M14 WT, Pgp-negative) and drug-resistant (M14 ADR, Pgp-positive) human...

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