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Supertrityl Radical and Cation: The Effect of a Large π-Surface for Intermole...

Nishiuchi(T),Hamazaki(S),Sato(H),Kubo(T) Org Lett 2026-05-01

...hexa-peri-hexabenzocoronenes (HBCs). X-ray analysis of the cation revealed a propeller-shaped structure forming a two-di...

Tay-Sachs disease models: From cellular and animal models to treatment perspe...

Suarez(DA),Leal(AF),Pachajoa(H),Granados-V... Mol Genet Metab 2026-06-00

...HEXA gene, resulting in deficient activity of β-hexosaminidase A (Hex-A). Loss of Hex-A function leads to the intralysos...

Synthesis and Hydrogen Adsorption Simulation of Carbonized Hyper-Cross-Linked...

Cheng(J),Cheng(X),Wang(Z),Wang(W) ACS Appl Mater Interfaces 2026-04-15

...hexa-heptagonal junction. The GCMC simulations indicate that the daidzein-derived HCPs reproduced the experimental trend...

Supramolecular Biopolymer Composed of a Doubly (His)6-Tagged Tandem Z-Domain ...

Razi(SG),Krichevsky(O),Wachtel(E),Albeck(S... ACS Synth Biol 2026-04-17

...hexa-histidine tags to both the N- and C-termini of the tandem Z-domain ((His)6-(Z)2-(His)6) and adding equimolar Zn2+ a...

Human Neuraminidase 3 reduces the severity of Tay-Sachs disease symptoms in a...

Basırlı(H),Seyrantepe(V) Neurochem Int 2026-05-00

...HEXA and NEU3, Hexa-/-Neu3-/-, were generated. Abnormal GM2 accumulation was revealed in the brains of Hexa-/-Neu3-/- mi...

Effects of hydrogen-bonding properties of formamide on complex formation with...

Maseda(M),Takamuku(T) Phys Chem Chem Phys 2026-04-16

...hexa-FA-Zn2+ complexes are formed in solutions. The high hydrogen-bonding ability of FA molecules markedly reduces the s...

Modeling Tay-Sachs Disease in Astrocyte-like Cells Reveals Significant Change...

Suárez-García(DA),Espejo-Mojica(AJ),Alméci... Int J Mol Sci 2026-07-22

...HexA by targeted knockdown of the HEXA gene in U87MG astrocytoma cells. The resulting cell line recapitulates key pathol...

Phosphoethanolamine-modified lipid A enables antimicrobial resistance and aty...

Sherman(ME),Yang(H),Rasko(DA),Kolb(J),Josh... Microbiol Spectr 2026-08-04

...hexa-acylated LPS is more stimulatory through the murine ortholog of this receptor complex. Altogether, this study chara...

Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA de...

Zimmer(E),Reif-Trauttmansdorff(T),Ciancone... bioRxiv 2026-07-08

...hexa- to octameric oligomers via a conserved N-terminal region of the CdhD subunit. This scaffold likely tethers CODH an...

Late-Onset Tay-Sachs Disease With SMALED-Like Muscle MRI Pattern Despite a Di...

Frezatti(RSS),Gonçalves(TAP),de Albuquerqu... J Peripher Nerv Syst 2026-09-00

...HEXA gene in each patient, confirmed to be in trans, and enzymatic testing demonstrated reduced β-hexosaminidase A activ...

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