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Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a pote...

Bateman(Katherine S),Cherney(Maia M),Mahur... J Med Chem 2011-06-06

...HexB) and PYR has been determined to 2.8 Å. PYR binds to the active site of HexB where several favorable van der Waals c...

Gene expression profiling suggests a pathological role of human bone marrow-d...

Jiang(Shih Sheng),Chen(Chung-Hsing),Tseng(... Aging (Albany NY) 2011-11-29

...HEXB, CTSK, SULF1, ADAMTS5, SPP1, COL8A2, GPNMB, TNFAIP6, and RPL29; those genes have been implicated in the bone loss a...

The influence of surface microroughness and hydrophilicity of titanium on the...

Vlacic-Zischke(J),Hamlet(S M),Friis(T),Ton... Biomaterials 2011-03-07

...HEXB, TPP1), were also differentially regulated. These results suggest that chemical (hydrophilic) modification of the S...

An open-label Phase I/II clinical trial of pyrimethamine for the treatment of...

Clarke(Joe T R),Mahuran(Don J),Sathe(Swati... Mol Genet Metab 2011-04-25

...HEXB (Sandhoff variant) genes. The enzyme deficiency in many patients with juvenile or adult onset forms of the disease ...

Classification of fowl adenoviruses by use of phylogenetic analysis and high-...

Marek(Ana),Günes(Ayse),Schulz(Evelyn),Hess... J Virol Methods 2011-05-17

...HexB) and pedestal (P1) region and loop 2 (L2) region (HexF1/HexR1) of the FAdV hexon gene were used for high-resolution...

Identification and expression profiling of Ceratitis capitata genes coding fo...

Pasini(Maria E),Intra(Jari),Gomulski(Ludvi... Gene 2011-03-31

...HEXB, have been recently identified on Drosophila sperm. These enzymes are involved in egg binding through interactions ...

[Hexosoaminidase gene expression in cholesteatoma in adults].

Rutkowska(Justyna),Olszewska(Ewa),Waniewsk... Otolaryngol Pol 2010-04-09

...HEXB mRNA in cholesteatoma. HEXA mRNA in CF was six times higher than in the controls. HEX mRNA expression found to be r...

[The pirymethamine influence on hexosoaminidase gene expression in synovial c...

Olszewski(Sławomir),Rutkowska(Justyna),Pop... Pol Merkur Lekarski 2010-05-26

...HEXB genes in the synovial cell culture derived from human synovial inflammatory fluid obtained from patients suffered f...

The phenylalanine hydroxylase c.30C>G synonymous variation (p.G10G) creates a...

Dobrowolski(Steven F),Andersen(Henriette S... Mol Genet Metab 2010-10-19

...HEXB, which has previously been associated with exon skipping in patients also creates a GGG triplet. We show that the m...

Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynoji...

Denny(Christine A),Heinecke(Karie A),Kim(Y... J Neurochem 2010-08-06

...Hexb) knockout (-/-) murine model of Sandhoff disease. In this study, we used a restricted ketogenic diet (KD-R) and NB-...

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