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Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphobla...

Krause(Sarah),Pfeiffer(Christian),Strube(S... Blood 2015-04-13

...Tyro3, Axl, and Mer) receptor Mer is upregulated in these leukemias. We examined the functional role of Mer in the CNS i...

Differential TAM receptor-ligand-phospholipid interactions delimit differenti...

Lew(Erin D),Oh(Jennifer),Burrola(Patrick G... Elife 2015-06-23

The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential...

Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological...

Suárez(Rosa M),Chevot(Franciane),Cavagnino... Eur J Med Chem 2014-08-26

...Tyro3. Our goal was to design a type II inhibitor specific for this family, i.e. able to interact with the allosteric po...

Expression and localization of receptor tyrosine kinase Tyro3 in rat brain.

Zhao(Quan-ming),Li(Ling-min),Zhang(Ce),Guo... Beijing Da Xue Xue Bao 2014-04-21

...Tyro3 protein in adult rat brains were detected by the avidin-biotin-peroxidase complex method.,Tyro3 was the most highl...

Development of a spontaneous liver disease resembling autoimmune hepatitis in...

Qi(Nan),Liu(Peipei),Zhang(Yue),Wu(Hui),Che... PLoS One 2014-03-05

...Tyro3, Axl and Mer (TAM) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH....

Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain d...

Li(Qiutang),Lu(Qingjun),Lu(Huayi),Tian(Shi... PLoS One 2014-02-05

...Tyro3, Axl and Mertk (TAM) triply knockout (TKO) mice exhibit systemic autoimmune diseases, with characteristics of incr...

Molecular pathways: MERTK signaling in cancer.

Cummings(Christopher T),Deryckere(Deborah)... Clin Cancer Res 2014-05-08

...Tyro3, Axl, MERTK) family, with a defined spectrum of normal expression. However, MERTK is overexpressed or ectopically ...

Comparative receptor tyrosine kinase profiling identifies a novel role for AX...

Son(Mi-Young),Seol(Binna),Han(Yong-Mahn),C... Hum Mol Genet 2014-11-26

...TYRO3 in terms of both their expression and phosphorylation levels were predominantly related to the maintenance of hPSC...

TAM receptor tyrosine kinases: expression, disease and oncogenesis in the cen...

Pierce(Angela M),Keating(Amy K) Brain Res 2014-08-15

...Tyro3, Axl, and MerTK, is prominently expressed during the development and function of the central nervous system (CNS)....

Biology of the TAM receptors.

Lemke(Greg) Cold Spring Harb Perspect Biol 2014-06-23

...Tyro3, Axl, and Mer--comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential ro...

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