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Inhibition of P-glycoprotein transport: a mechanism for endocrine disruption in…

Kleinow(KM),Hummelke(GC),Zhang(Y),Uppu(P),Ba… Mar Environ Res 2004-00-00

...pgp transport function. E2, in competitive transport preparations with Rhodamine 123 (Rho123), a pgp substrate, demonstr...

P-glycoprotein down-regulates expression of breast cancer resistance protein in…

Bark(H),Xu(HD),Kim(SH),Yun(J),Choi(CH) FEBS Lett 2008-07-23

...Pgp. Pharmacological inhibitors (PSC833 or verapamil) or siRNA for Pgp inhibited the down-regulation of BCRP, which was ...

Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic st…

Snelgrove(RJ) Eur J Pharmacol 2011-09-30

...PGP) is a neutrophil chemoattractant derived from extracellular matrix collagen and implicated in diseases such as COPD ...

Effect of combination of suboptimal concentrations of P-glycoprotein blockers o…

Hwang(M),Ahn(CH),Pine(PS),Yin(JJ),Hrycyna(CA… Int J Cancer 1996-01-26

...Pgp. We could also show that the combination of suboptimal doses of these blockers can restore the uptake of the Pgp sub...

Distinct groups of multidrug resistance modulating agents are distinguished by …

Nagy(H),Goda(K),Fenyvesi(F),Bacsó(Z),Szilasi… Biochem Biophys Res Commun 2004-03-19

P-glycoprotein (Pgp) is one of the ABC transporters responsible for the multidrug resistance of cancer cells. The confor...

Projection structure of P-glycoprotein by electron microscopy. Evidence for a c…

Lee(JY),Urbatsch(IL),Senior(AE),Wilkens(S) J Biol Chem 2002-10-18

...Pgp) from mouse has been studied by electron microscopy and image analysis. Two-dimensional crystals of Pgp in a lipid b...

ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells.

Senior(AE),al-Shawi(MK),Urbatsch(IL) J Bioenerg Biomembr 1995-02-00

...Pgp) from Chinese hamster ovary cells was studied. Catalytic characteristics were established for Pgp both in its natura...

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein al…

Devine(SE),Ling(V),Melera(PW) Proc Natl Acad Sci U S A 1992-05-15

...pgp drug recognition and efflux. Moreover, they indicate a close functional homology between pgp and the cystic fibrosis...

Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionat…

Hill(BT),Deuchars(K),Hosking(LK),Ling(V),Whe… J Natl Cancer Inst 1990-04-04

...Pgp overexpression occurred in these cells, despite a lack of Pgp gene amplification or of significant alteration in Pgp...

P-glycoprotein-mediated multidrug resistance is modulated by pretreatment with …

Haberl(I),Swatonek(H),Schaufler(K),Ulsperger… Int J Oncol 1998-05-00

...Pgp-mediated transport, but in contrast maximized phosphorylation of Pgp (16 h) and Pgp protein expression (48 h), respe...

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