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Sappanone A, a potential natural inhibitor of PI3K, alleviates metabolic dysfun…

Qiao(X),Li(Q),Fan(R),Cheng(Y),Zeng(Q),Xue(H)… Biochem Pharmacol 2025-12-00

...COL1a1 in LX-2 cells, further confirming the dependence of SA on PI3K activity. In conclusion, we identified SA as a pot...

LC3 and GABARAP independent autophagy of misfolded procollagen in mouse osteobl…

Makareeva(E),Omari(S),Roberts-Pilgrim(AM),Go… Autophagy 2025-12-00

Bone synthesis should depend on autophagy because over 10% of type I procollagen (PC1) - a heterotrimer of COL1A1 and CO...

NaIO3-induced RPE toxicity leads to chorioretinal atrophy, scleral remodeling, …

Suzuki(T),Nagahara(M),Hayashi(K),Shiraya(T),… Exp Eye Res 2025-12-00

...COL1A1 expression, and reduced collagen fibril diameter-hallmarks of scleral extracellular matrix remodeling. Fer-1 trea...

Paederoside, an active metabolite of Paederia scandens, alleviates osteoporosis…

Liu(Z),He(W),Zhang(J),Su(B),Mu(J),Wang(X) Front Pharmacol 2025-00-00

...Col1a1, Bglap, Osterix, and Runx2) and downregulated osteoclastogenesis-related markers (RANKL, NFATc1, Acp5, Ctsk, and ...

Network toxicology and mechanistic insights reveal the oxytocin receptor (OXTR)…

Kong(Y),Li(S),Wang(C),Ge(J) Toxicol Appl Pharmacol 2025-12-00

...COL1A1 and IL-6 expression, while reducing CACNA1C expression. OXTR knockdown reversed these effects. Collectively, our ...

Intersecting Pathologies: COL1A1-Related Syndrome in the Setting of Childhood-O…

Pelineagră(OE),Golu(I),Chiriţă-Emandi(A),Bal… Diagnostics (Basel) 2025-09-25

Background: Type I collagen is the most abundant protein of the extracellular matrix. Pathogenic variants in COL1A1 or C...

Interaction between nuclear-translocated cellular communication network factor …

Nguyen(XT),Kubota(S),Takigawa(M),Nishida(T) J Cell Commun Signal 2025-12-00

...Col1a1 and Acta2, at the gene and protein levels. These findings indicate that CCN2 translocated to the nucleus interact...

Integrative analysis of mRNA, lncRNA, circRNA, and miRNA to investigate the ant…

Liu(J),Wu(X),Guo(J),Zhou(L),Liu(X),Zhu(L),Ma… BMC Genomics 2025-09-25

...COL1A1 and α-SMA, were enriched in pathways including cell migration, cell adhesion, and extracellular matrix. Furthermo...

Integrating transcriptomic and epigenomic data to identify potential biomarkers…

Mitra(T),Yadav(DV),Kumari R(S),Agrawal(P),Ja… Sci Rep 2025-09-25

...COL1A1) with high diagnostic potential. Overall, we obtained 18 genes that could serve as novel diagnostic biomarkers an...

Phocaeicola plebeius oral treatment improve fibrosis by reversing cirrhosis-rel…

Sharma(SP),Cha(MG),Kwon(GH),Song(SH),Park(JH… Life Sci 2025-11-15

...COL1A1, LTBP2, S100A6, and SMCO2. Additionally, P. plebeius treatment decreased the expression of hepatotoxicity-related...

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