...KRAS tumors. Besides the inhibition of the EGFR pathway, Cetuximab may exert anti-tumor effects through antibody-depende...
...KRAS mutation analysis of codons 12/13. The KRAS-evaluable pts (n=540) were analyzed statistically to evaluate treatment...
...KRAS mutations are associated with poor response. Determining the presence of EGFR/KRAS mutations in tumor DNA shed into...
...KRAS in tumor tissue is being analyzed when archived material is available.,Enrollment into the intermittent cohort is c...
...KRAS 2 exons were amplified and sequenced.,Tumor samples were collected from 65/88 eligible participants. 50 (81%) were ...
...KRAS mut than in KRAS-wild type (WT) tumors (2.26 vs 2.77; Mann-Whitney U test, p=0.022). A logistic regression model wi...
...KRAS mutations (14/92; 15%) had shorter OS and PFS vs wild-type KRAS (78/92; 85%); HR 1.73 and 1.37, respectively (ns). ...
...KRAS mutations are found in tumors refractory to these agents (Pao et al, PLoS Med '05). Moreover, EGFR and KRAS mutatio...
...KRAS in 4 of 34 (12%). In the 11 patients with partial responses, mutations in EGFR were found in 9 (82%) and in KRAS in...
...kRAS mutation analysis was performed on a set of 293 formalin-fixed tissue samples. Tumor cells were microdissected to e...
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