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TP53 BRCA1 CRISPR single-cell cancer

Jackman(D M),Sequist(L V),Cioffredi(L),Rui... J Clin Oncol 0000-00-00

...KRAS mutations. A total of 121 mutations in EGFR or KRAS were detected. 75 pts had a sensitizing EGFR mutation. (RR = 63...

Ho(C),Davies(A M),Lara(P N),Chew(H K),Beck... J Clin Oncol 0000-00-00

...KRAS mutations, p16 and APC gene promoter methylation.,Pemetrexed 500 mg/m day 1 with ABI 007 260 mg/m is feasible and w...

Janne(P A),Schellens(J H),Engelman(J A),Ec... J Clin Oncol 0000-00-00

...KRAS, within the phase I study are reported.,NSCLC pts (n=42) received PF 16 mg (n=1), 30 mg (n=2), 45 mg, the MTD (n=33...

Tzekova(V),Cebotaru(C),Ciuleanu(T E),Damja... J Clin Oncol 0000-00-00

...KRAS gene mutations. MEK1/2 inhibition block the Raf/MEK/ERK pathway since these kinases lie downstream of Ras, and ERK1...

Bokemeyer(C),Bondarenko(I),Hartmann(J T),D... J Clin Oncol 0000-00-00

...KRAS mutation status.,In general, the population with tissue available for KRAS analysis (n=233) was representative of t...

Tejpar(S),Peeters(M),Humblet(Y),Vermorken(... J Clin Oncol 0000-00-00

...KRAS mutation analysis.,In Arm A, 45 pts were randomized: 19 pts (42%) were KRAS wt, 19 pts (42%) were KRAS mt, and 7 pt...

Loupakis(F),Pollina(L),Stasi(I),Masi(G),Fu... J Clin Oncol 0000-00-00

...KRAS mutational status are ongoing. Final data will be presented at the meeting. Supported by A.R.C.O.,No significant fi...

Siena(S),Tabernero(J),Burkes(R L),Cassidy(... J Clin Oncol 0000-00-00

...KRAS mutational status in both arms as a potential biomarker for pmab activity in combination with FOLFOX as first-line ...

Di Fiore(F),Van Cutsem(E),Laurent-Puig(P),... J Clin Oncol 0000-00-00

...KRAS mut was detected in 98 pts including 40/107 (37.4%) pts with SD and 58/97 (59.8%) with PD. All responders were KRAS...

Peeters(M),Wilson(G),Ducreux(M),Cervantes(... J Clin Oncol 0000-00-00

...KRAS mutational status in both arms as a potential biomarker for pmab activity combined with FOLFIRI. The study includes...

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