...KRAS gene mutation ratio was 12.7% (7/55). Inverse relationship between KRAS and EGFR mutations in the non-small-cell lu...
...KRAS mutation. No other KRAS mutant case was scored as EGFR-amplified by either method. EGFR was positive by IHC in 28 c...
...KRAS mutations cannot account for all resistant cases. Preclinical data suggested that MET could interfere with anti-EGF...
...KRAS mutated tumors than in non mutated tumors (p<.04). In Cox multivariate analysis adjusted for age and gender KRAS an...
...KRAS status of these pts.,KRAS mutations were detected in 19 samples (40%) from the KRAS evaluable population. At the en...
...KRAS gene in tumors has been shown to be a predictive biomarker of response to anti-EGFr antibody monotherapy in mCRC. T...
...KRAS mutations are found in tumors refractory to these agents (Pao et al, PLoS Med '05). Moreover, EGFR and KRAS mutatio...
...KRAS in 4 of 34 (12%). In the 11 patients with partial responses, mutations in EGFR were found in 9 (82%) and in KRAS in...
...kRAS mutation analysis was performed on a set of 293 formalin-fixed tissue samples. Tumor cells were microdissected to e...
...KRAS2 exon 2).,All 26 pts were evaluated for response and toxicity. There were 0 CRs, 1 PR (response duration = 5 months...
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